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Basic information

CohesinDB ID: CDBP00421327

Locus: chr21-45734384-45735074

Data sourse: GSE67783, ENCSR153HNT, GSE86191

Cell type: K-562, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 84% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 53%, "14_ReprPCWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, ZSCAN5C, SOX2, XBP1, FOXA1, SUZ12, ZFHX2, ATF3, CBFB, TP63, ESR1, USF2, CTCF, SND1, IRF4, RAD51, ZNF528, GTF2F1, RBPJ, TFAP2C, POU2F2, MYCN, POU5F1, ZNF263, RUNX1T1, ZBTB48, STAT1, ERG, OGG1, MYC, SMARCA4, GRHL3, STAT3, XRCC5, DNMT3B, ARNTL, NR3C1, CEBPB, KMT2A, EZH2, GRHL2, EBF3, ZKSCAN5, GATA2, FLI1, RUNX1, SMC1A, EZH2phosphoT487, SIN3A, ZFX, POU4F2, TET2, ZNF549, PRDM10, TWIST1, RARA, ZNF35, TAF15, CDK6, GATA4, ARNT, PBX3, CHD1, FOS, MED1, KDM6B, KLF9, BCL11A, TFAP2A, REST, CTBP2, TCF3, AATF, SMC3, STAG1, TRP47, TBL1X, FOXA2, EBF1, ZNF600, ZNF692, GTF2B, WT1, MEF2C, CDK9, HOXB13, YY1, RELA, NEUROD1, SP140, ZIC2, HIF1A, OTX2, GATA3, MAX, ZNF143, ZFP69B, NCOA3, NR2F2, NR2F1, TP53, PKNOX1, ZNF334, AR, RXR, HEXIM1, HSF1, BRD4, SCRT1, MAZ, AHR

Target gene symbol (double-evidenced CRMs): TSPEAR,PCBP3,FAM207A,ADARB1,FTCD,TRPM2,COL6A2,UBE2G2

Function elements

Human SNPs: Diffusing_capacity_of_carbon_monoxide

Number of somatic mutations (coding): 7

Number of somatic mutations (non-coding): 7

Related genes and loops

Related gene: ENSG00000142185, ENSG00000175894, ENSG00000184787, ENSG00000160256, ENSG00000197381, ENSG00000183570, ENSG00000142173, ENSG00000160282,

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Deatailed information for cohesin site CDBP00421327