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Basic information

CohesinDB ID: CDBP00421331

Locus: chr21-45744922-45747032

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE67783, GSE72082, GSE86191, GSE116868, GSE25021, GSE111913, GSE105028, GSE51234, ENCSR000ECE, GSE206145-NatGen2015, ENCSR153HNT, ENCSR703TNG, GSE131606, GSE126755

Cell type: MCF-7, H1-hESC, Fibroblast, HCT-116, MB157, DKO, RT-112, K-562, GP5d, Neutrophil, HSPC, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 6% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.867

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 84% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 37%, "5_TxWk": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: CHD8, MYCN, ZNF263, NFATC1, ZFX, WT1, ZBTB48, ZBTB33, BCL3, YY1, RELA, MYC, RAD21, SP140, APC, PBX3, ZNF143, DNMT3B, ZEB1, NCOA3, ESR1, OCA2, CTCF, SSRP1, HSF1, TCF3, CLOCK, MAZ, STAG1, EED

Target gene symbol (double-evidenced CRMs): ADARB1,TRPM2,COL6A2,TSPEAR,FAM207A,PCBP3,UBE2G2,FTCD

Function elements

Human SNPs: Immune_reponse_to_smallpox_(secreted_IFN-alpha)

Number of somatic mutations (coding): 29

Number of somatic mutations (non-coding): 29

Related genes and loops

Related gene: ENSG00000142185, ENSG00000175894, ENSG00000184787, ENSG00000160256, ENSG00000197381, ENSG00000183570, ENSG00000142173, ENSG00000160282,

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Deatailed information for cohesin site CDBP00421331