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Basic information

CohesinDB ID: CDBP00421332

Locus: chr21-45747248-45748980

Data sourse: GSE206145-GSE177045, GSE104888, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, ENCSR000BLY, GSE105028, GSE131606, GSE108869, ENCSR330ELC, GSE25021, GSE115602, ENCSR000EFJ, ENCSR000BTU, GSE67783, GSE86191, GSE115250, GSE138405, GSE76893, GSE206145-NatGen2015, ENCSR703TNG, GSE116344, ENCSR000EHW, ENCSR000EHX, ENCSR984DZW, ENCSR000BTQ, ENCSR853VWZ, GSE129526, ENCSR000HPG, GSE111913, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, ENCSR000ECS

Cell type: MCF-7, Fibroblast, HCT-116, Hela-Kyoto, MB157, RH4, Ishikawa, A-549, DKO, HeLa-S3, RT-112, IMR-90, SK-N-SH, K-562, TC-32, HSPC, HuCC-T1, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 16% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.800

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 84% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 33%, "7_Enh": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: TRIM25, PGR, ZNF675, FOSL1, ZNF660, XBP1, PATZ1, FOXA1, SUZ12, MLL4, ZFHX2, TFAP4, ATF3, NFIC, ZC3H8, ZFP64, PRDM1, IKZF3, WDHD1, ZNF444, CBFB, ZNF189, SMARCE1, DPF1, TP63, MITF, ZNF629, MYOG, KLF5, TEAD1, TRIM28, ZNF121, ETV1, SNAI2, NFE2L2, ELF1, ZNF217, ESR1, OCA2, TP73, PITX3, LMO2, USF2, CTCF, JUN, TCF12, BAF155, KLF1, EP300, ZBTB20, MNT, DPF2, TRIM24, GLI4, RAD51, E2F1, ZNF528, GTF2F1, PDX1, TFAP2C, RBPJ, ZNF573, GLIS1, MYCN, ZNF263, KDM4C, CTBP1, ZSCAN21, ZBTB17, DUX4, ZBTB48, SRF, ERG2, SP4, ERG, ZBTB21, HOXC5, ASCL1, MYC, SMARCA4, RAD21, GRHL3, NKX2-1, GABPA, STAT3, XRCC5, NKX3-1, ZNF398, RCOR1, DNMT3B, ZNF639, NR3C1, CEBPB, SRSF3, CREB1, EZH2, KLF8, GRHL2, FEZF1, EBF3, KLF17, HDAC2, GATA2, GATAD2B, SIX2, FLI1, MXI1, MRTFB, NCOA2, ZNF554, MYF5, RUNX1, AHRR, SMC1A, CBX1, BCL6, NKX2-2, EZH2phosphoT487, SIN3A, ZFX, ZNF534, AFF4, POU4F2, SMAD3, TET2, ERG3, SMARCC1, PRDM10, ZNF549, TWIST1, CREBBP, ZNF384, ZNF35, ZXDC, GATA4, ZNF184, ARNT, DAXX, PBX4, ZBTB10, ZEB2, PBX3, MAFB, SP2, FOS, SMARCB1, CDK8, MED1, ZNF558, MYB, SCRT2, PIAS1, KLF9, ZNF41, MAFK, NIPBL, TFAP2A, GSPT2, BCL11A, USF1, REST, ZNF479, ATF7, CTBP2, PHIP, GLIS2, MBD2, AATF, SMC3, ELL2, STAG1, NFATC3, ZNF394, PAX7, TRP47, CBX3, CHD2, SS18, ZNF600, ZNF692, WT1, ZNF30, KDM1A, YY1, RELA, JUNB, NEUROD1, SP140, ZIC2, HIF1A, TCF4, GATA3, MAX, NRIP1, ZNF143, MTA1, HAND2, PLAG1, SP7, NCOA3, NR2F2, NR2F1, TCF7L2, KDM5B, ZNF687, TP53, PKNOX1, ZNF334, MYOD1, EGR2, BRD2, BHLHE40, AR, TAF1, ZNF324, EGLN2, ZNF366, EGR1, ZBTB42, HSF1, BRD4, JUND, SCRT1, CUX1, MAZ, ZSCAN23, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): COL6A2,PCBP3,ADARB1,FAM207A,UBE2G2,FTCD,TSPEAR,TRPM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 9

Number of somatic mutations (non-coding): 9

Related genes and loops

Related gene: ENSG00000142185, ENSG00000175894, ENSG00000184787, ENSG00000160256, ENSG00000197381, ENSG00000183570, ENSG00000142173, ENSG00000160282,

eachgene

Deatailed information for cohesin site CDBP00421332