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Basic information

CohesinDB ID: CDBP00421335

Locus: chr21-45751471-45751832

Data sourse: ENCSR000BLD, GSE67783, GSE86191, ENCSR000BLY, ENCSR000EHW, ENCSR153HNT, ENCSR000EHX, GSE25021

Cell type: MCF-7, H1-hESC, HCT-116, SK-N-SH, K-562, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.933

Subunit: SMC3,Rad21,SA1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 59%, "14_ReprPCWk": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: POU2F2, CHD8, POU5F1, ZNF263, ZFX, POU4F2, ZSCAN16, GTF2B, XBP1, FOXA1, ERG3, ERG2, PBX2, HOXB13, ZFHX2, ERG, RELA, MYC, RAD21, GRHL3, ATF2, ZNF519, XRCC5, ZNF143, HNRNPH1, MED1, ARNTL, KLF4, ZNF573, EZH2, ESR1, OCA2, EGR2, CTCF, BAF155, ARRB1, AR, GATA2, IRF4, BRD4, STAG1

Target gene symbol (double-evidenced CRMs): SLC19A1,ADARB1,PCBP3,COL6A2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 1

Number of somatic mutations (non-coding): 1

Related genes and loops

Related gene: ENSG00000197381, ENSG00000173638, ENSG00000183570, ENSG00000142173,

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Deatailed information for cohesin site CDBP00421335