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Basic information

CohesinDB ID: CDBP00421340

Locus: chr21-45764836-45765653

Data sourse: GSE67783, ENCSR153HNT, GSE86191

Cell type: K-562, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 58%, "14_ReprPCWk": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, TRIM25, SMARCA2, XBP1, FOXA1, SUZ12, ZFHX2, HDGF, ATF3, NFIC, CTCFL, PRDM1, ZNF444, CBFB, MECOM, TP63, MYOG, MAF, TEAD1, ELF1, RBM39, ZNF26, NFE2L2, LMO2, ESR1, OCA2, TP73, PITX3, CTCF, TCF12, EP300, ZNF528, SMC1, TEAD4, GTF2F1, TFAP2C, GLIS1, POU2F2, CHD8, BRD1, MYCN, POU5F1, TOP2A, KDM4C, MTA2, ZBTB48, STAT1, DDX5, ERG2, ERG, OGG1, ZNF341, MYC, SMARCA4, HOMEZ, RAD21, FOXP2, GRHL3, NKX2-1, STAT3, APC, NKX3-1, RCOR1, DNMT3B, HNRNPH1, NR2F6, NR3C1, STAT5B, KMT2A, CREB1, EZH2, EBF3, SPI1, HDAC2, GATA2, FLI1, MXI1, NCOA2, ZIM3, MYF5, RUNX1, SMC1A, BCL6, CBX1, EZH2phosphoT487, SIRT6, CRY1, SIN3A, ZFX, ZNF534, SMAD3, TET2, ERG3, TWIST1, CREBBP, ZNF384, RARA, NOTCH1, ZBTB2, RUNX2, ARNT, ZNF48, PRDM9, ATF2, PBX3, FOS, CHD1, SMARCB1, CDK8, TEAD3, ZEB1, KDM6B, MYB, PIAS1, SMAD1, ZNF3, NCOA1, ZNF22, USF1, BCL11A, HNF4A, REST, POU2F3, ATF7, AATF, SMC3, STAG1, TRP47, ZNF283, CBFA2T2, MEF2B, TBL1X, FOXA2, EBF1, CHD2, ZNF600, WT1, CDK9, HOXB13, KDM1A, YY1, RELA, SP140, ZIC2, HIF1A, TCF4, GATA3, TAL1, MAX, NRIP1, ZNF143, HAND2, ZFP69B, BCL11B, NCOA3, NEUROG2, NR2F1, KDM5B, TP53, ZNF334, MYOD1, EGR2, TBX21, BHLHE40, AR, PAX3-FOXO1, ARID4B, RXR, EGLN2, EGR1, HEXIM1, HSF1, BRD4, JUND, CLOCK, MAZ, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): PCBP3,SLC19A1,ADARB1,COL6A2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 9

Number of somatic mutations (non-coding): 9

Related genes and loops

Related gene: ENSG00000197381, ENSG00000173638, ENSG00000183570, ENSG00000142173,

eachgene

Deatailed information for cohesin site CDBP00421340