- Basic information
- CohesinDB ID: CDBP00421341
- Locus: chr21-45766057-45770234
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, GSE72082, ENCSR000BSB, GSE116868, ENCSR000BLY, GSE105028, GSE121355, GSE131606, ENCSR330ELC, GSE108869, GSE25021, ENCSR000BUC, GSE115602, ENCSR000EFJ, ENCSR000BTU, GSE93080, ENCSR000DZP, ENCSR000EAC, GSE67783, ENCSR000BKV, GSE115250, GSE138405, GSE86191, GSE76893, GSE206145-NatGen2015, GSE112028, GSE130135, ENCSR199XBQ, ENCSR703TNG, GSE106870, GSE116344, GSE94872, ENCSR000EEG, GSE76815, ENCSR000BLS, ENCSR000EHW, ENCSR000ECE, ENCSR000BMY, ENCSR000EHX, ENCSR767DFK, ENCSR984DZW, GSE97394, ENCSR217ELF, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, GSE131956, GSE110061, GSE129526, GSE111913, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, GSE38411
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Cell type: RH4, GM2610, CVB-hiPSC, GM19240, HSPC, TC-32, HuCC-T1, H9-hESC, GM2630, Fibroblast, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, H1-hESC, MB157, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, RT-112, HUES64, MCF-7, GM12892, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, A-549, HUVEC, GM19238, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 31% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.556
- Subunit: SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
83% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 45%,
"7_Enh": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, TRIM25, SMARCA2, XBP1, FOXA1, SUZ12, ZFHX2, HDGF, ATF3, NFIC, CTCFL, PRDM1, ZNF444, CBFB, MECOM, TP63, MYOG, MAF, TEAD1, ELF1, RBM39, ZNF26, NFE2L2, LMO2, ESR1, OCA2, TP73, PITX3, CTCF, TCF12, EP300, ZNF528, SMC1, TEAD4, GTF2F1, TFAP2C, GLIS1, POU2F2, CHD8, BRD1, MYCN, POU5F1, TOP2A, KDM4C, MTA2, ZBTB48, STAT1, DDX5, ERG2, ERG, OGG1, ZNF341, MYC, SMARCA4, HOMEZ, RAD21, FOXP2, GRHL3, NKX2-1, STAT3, APC, NKX3-1, RCOR1, DNMT3B, HNRNPH1, NR2F6, NR3C1, STAT5B, KMT2A, CREB1, EZH2, EBF3, SPI1, HDAC2, GATA2, FLI1, MXI1, NCOA2, ZIM3, MYF5, RUNX1, SMC1A, BCL6, CBX1, EZH2phosphoT487, SIRT6, CRY1, SIN3A, ZFX, ZNF534, SMAD3, TET2, ERG3, TWIST1, CREBBP, ZNF384, RARA, NOTCH1, ZBTB2, RUNX2, ARNT, ZNF48, PRDM9, ATF2, PBX3, FOS, CHD1, SMARCB1, CDK8, TEAD3, ZEB1, KDM6B, MYB, PIAS1, SMAD1, ZNF3, NCOA1, ZNF22, USF1, BCL11A, HNF4A, REST, POU2F3, ATF7, AATF, SMC3, STAG1, TRP47, ZNF283, CBFA2T2, MEF2B, TBL1X, FOXA2, EBF1, CHD2, ZNF600, WT1, CDK9, HOXB13, KDM1A, YY1, RELA, SP140, ZIC2, HIF1A, TCF4, GATA3, TAL1, MAX, NRIP1, ZNF143, HAND2, ZFP69B, BCL11B, NCOA3, NEUROG2, NR2F1, KDM5B, TP53, ZNF334, MYOD1, EGR2, TBX21, BHLHE40, AR, PAX3-FOXO1, ARID4B, RXR, EGLN2, EGR1, HEXIM1, HSF1, BRD4, JUND, CLOCK, MAZ, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): COL6A2,ADARB1,SLC19A1,PCBP3
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 31
- Number of somatic mutations (non-coding): 20
- Related genes and loops
- Related gene:
ENSG00000197381,
ENSG00000173638,
ENSG00000183570,
ENSG00000142173,
- Related loop:
chr21:45125000-45150000~~chr21:45750000-45775000,
chr21:45200000-45225000~~chr21:45750000-45775000,
chr21:45325000-45350000~~chr21:45750000-45775000,
chr21:45550000-45575000~~chr21:45750000-45775000,
chr21:45550000-45575000~~chr21:45775000-45800000,
chr21:45554119-45557159~~chr21:45768109-45769458,
chr21:45625000-45650000~~chr21:45750000-45775000,
chr21:45640592-45641966~~chr21:45767982-45769723,
chr21:45650000-45675000~~chr21:45750000-45775000,
chr21:45750000-45775000~~chr21:45875000-45900000,
chr21:45750000-45775000~~chr21:45900000-45925000,
chr21:45750000-45775000~~chr21:46100000-46125000,