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Basic information

CohesinDB ID: CDBP00421351

Locus: chr21-45796587-45797584

Data sourse: GSE206145-GSE177045, GSE72082, GSE138405, ENCSR000BLY, GSE206145-NatGen2015, ENCSR000EDE, ENCSR153HNT, GSE112028, ENCSR703TNG, GSE126990, GSE50893

Cell type: MCF-7, GM12892, Fibroblast, Hela-Kyoto, HeLa-S3, SK-N-SH, K-562, HeLa-Tet-On

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.911

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 35%, "14_ReprPCWk": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: POU2F2, SMC1A, CEBPA, EZH2phosphoT487, HDAC1, TOP2A, XBP1, ZBTB17, MAFF, GTF2B, STAT1, FOXA1, SRF, ZNF473, SUZ12, ZNF662, HOXB13, ZNF596, ERG, RELA, ZBTB2, MYC, RAD21, PRDM1, ARNT, ZNF444, IKZF3, GABPA, ZNF8, ZNF143, RCOR1, MED1, CEBPB, NCOA3, EZH2, LMO2, ESR1, OCA2, PKNOX1, CTCF, MAFK, AR, SSRP1, GATAD2B, ZNF366, SCRT1, ZNF512B, CLOCK, ZNF316

Target gene symbol (double-evidenced CRMs): SLC19A1,PCBP3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 6

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000173638, ENSG00000183570,

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Deatailed information for cohesin site CDBP00421351