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Basic information

CohesinDB ID: CDBP00421354

Locus: chr21-45803374-45804235

Data sourse: GSE67783, ENCSR153HNT, GSE86191

Cell type: K-562, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 58%, "14_ReprPCWk": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, TRIM25, XBP1, FOXA1, SUZ12, RXRB, TFAP4, ZBTB7B, ATF3, THRB, ZFP64, MXD4, MECOM, TP63, TRIM28, ESR1, OCA2, CTCF, JUN, EP300, KLF1, E4F1, LMO1, SOX5, E2F4, FOXA3, ZNF175, GATAD2A, MLX, TFAP2C, POU2F2, CHD8, BRD1, MYCN, ZNF263, TOP2A, ZBTB48, ZSCAN5A, SAP130, ERG2, HNF4G, ZNF300, ERG, ASCL1, OGG1, MYC, SMARCA4, RAD21, GRHL3, RXRA, GABPA, STAT3, XRCC5, ZNF614, PRDM14, DNMT3B, NR2F6, NR3C1, HNRNPL, CREB1, EZH2, GRHL2, EBF3, GABPB1, SPI1, MIXL1, KLF17, HDAC2, GATA2, ZNF644, DRAP1, HCFC1R1, NFIL3, RUNX1, SMC1A, EZH2phosphoT487, SIRT6, SOX13, ZFX, TET2, ERG3, SP5, PRDM10, RARA, CREBBP, NOTCH1, TAF15, GATA4, ARNT, ZNF48, SMAD4, CHD1, FOS, TEAD3, MYB, SCRT2, ZNF3, SETDB1, SP1, HNF4A, IKZF5, REST, HNRNPLL, TCF3, FOXP1, GLIS2, AATF, SMC3, STAG1, NFATC3, TRP47, CBFA2T2, FOXA2, MIER2, ZNF600, WT1, KDM1A, YY1, RELA, NEUROD1, SP140, ZIC2, HIF1A, GATA3, TAL1, MAX, ZNF449, NRIP1, PLAG1, CBX2, BCL11B, ZNF141, NCOA3, NR2F1, NEUROG2, KDM5B, ZNF334, MYOD1, EGR2, PHOX2B, ELF3, AR, RXR, ZBTB42, HEXIM1, ZBTB26, HSF1, BRD4, JUND, MAZ, AHR

Target gene symbol (double-evidenced CRMs): ITGB2-AS1,POFUT2,SLC19A1,ADARB1,ITGB2,COL18A1,FAM207A,PCBP3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 7

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381, ENSG00000186866, ENSG00000182871, ENSG00000173638, ENSG00000183570,

eachgene

Deatailed information for cohesin site CDBP00421354