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Basic information

CohesinDB ID: CDBP00421357

Locus: chr21-45810206-45810279

Data sourse: GSE120943, GSE98367

Cell type: Monocytes, Macrophage

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 65%, "14_ReprPCWk": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, SOX2, NME2, XBP1, FOXA1, PBX2, ATF3, PRDM1, PAX5, ZSCAN4, MYOG, TRIM28, LMO2, ESR1, CTCF, MNT, IRF4, SOX6, ZNF528, ZNF175, GLIS1, NANOG, CHD8, ZNF263, MYCN, RUNX1T1, POU5F1, ZBTB48, DUX4, TBP, ERG, ASCL1, OGG1, MYC, SMARCA4, FOXP2, RAD21, GRHL3, GABPA, STAT3, APC, XRCC5, NR3C1, CEBPB, KMT2A, EZH2, GRHL2, SPI1, PCBP1, MYF5, RUNX1, SMC1A, EZH2phosphoT487, ZFX, TET2, NFXL1, CREBBP, ZNF384, TAF15, CDK6, ETV6, KDM6B, EVI1, FOXP1, AATF, SMC3, STAG1, TRP47, PPARG, AGO1, FOXA2, WT1, HOXB13, YY1, RELA, NEUROD1, SP140, ZIC2, HIF1A, OTX2, MAX, ZNF143, NCOA3, NR2F1, NEUROG2, TP53, MYOD1, AR, RXR, EGLN2, ZBTB42, HEXIM1, HSF1, BRD4, MAZ, AHR

Target gene symbol (double-evidenced CRMs): ITGB2,POFUT2,ITGB2-AS1,SLC19A1,FAM207A,ADARB1,COL18A1,PCBP3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 2

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000197381, ENSG00000186866, ENSG00000182871, ENSG00000173638, ENSG00000183570,

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Deatailed information for cohesin site CDBP00421357