- Basic information
- CohesinDB ID: CDBP00421360
- Locus: chr21-45813685-45816501
-
Data sourse: GSE38395, GSE104888, GSE67783, GSE110061, GSE206145, GSE206145-NatGen2015, GSE120943, ENCSR153HNT, GSE126755
-
Cell type: RPE, Fibroblast, HCT-116, Monocytes, hLCL, K-562, Neutrophil, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,SMC3
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
83% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"15_Quies": 59%,
"14_ReprPCWk": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: ZNF391, ZNF195, ZNF621, MEIS2, FOXA1, SUZ12, PBX2, ZFHX2, ZBTB7B, HNRNPK, HDGF, INSM2, ZBTB5, PRDM1, ZNF444, KLF14, ZNF629, ELF1, BCLAF1, ZNF26, ZNF571, ZIK1, E4F1, KLF1, MNT, ZNF157, DPF2, TRIM24, RFX5, GLI4, ZNF211, ZNF512B, ZNF776, ZNF175, EHMT2, EED, POU2F2, ZNF239, POU5F1, ID3, ZSCAN21, ZSCAN5A, NONO, ZNF488, ERG2, ZNF300, SMARCA4, RFX1, TSHZ1, RAD21, NKX2-1, ZNF8, STAT3, ZNF398, NFE2, LEF1, ZNF639, ESRRA, HNRNPL, KMT2A, CREB1, KLF8, ARHGAP35, HES1, HDAC2, SSRP1, GATAD2B, ZNF146, ZNF785, SMARCA5, MRTFB, SALL2, HDAC1, SIRT6, ZNF707, ZFX, ZNF747, ZNF658, ZFP37, ZNF473, ERG3, ZNF169, RUNX2, OSR2, ZNF184, PBX4, NFIB, ZBTB10, PBX3, FOS, CDK8, ZEB1, ZNF670, NCOA1, TBX5, STAT5A, SP1, PHF20, ATF7, ASH2L, TCF3, BCOR, ZNF623, KLF13, FOXA2, ZNF207, MTA3, NFATC1, WT1, ZNF493, ZNF662, BCL3, RELA, TARDBP, ZNF148, ZNF155, ZNF521, ZIC2, ZNF311, ZNF143, ZNF592, SP7, ZNF544, ZNF791, PKNOX1, BCL6B, EGR2, ZNF843, RBAK, ZNF324, ZNF280D, BRD4, CLOCK, ZSCAN23, AHR
- Target gene symbol (double-evidenced CRMs): ITGB2-AS1,ITGB2,POFUT2,FAM207A,SLC19A1,PCBP3,ADARB1,COL18A1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 44
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000160255,
ENSG00000227039,
ENSG00000160256,
ENSG00000197381,
ENSG00000186866,
ENSG00000182871,
ENSG00000173638,
ENSG00000183570,
- Related loop:
chr21:44925000-44950000~~chr21:45800000-45825000,
chr21:44950000-44975000~~chr21:45800000-45825000,
chr21:44975000-45000000~~chr21:45800000-45825000,
chr21:45125000-45150000~~chr21:45800000-45825000,
chr21:45136450-45139355~~chr21:45818438-45821813,
chr21:45136469-45139375~~chr21:45817787-45821574,
chr21:45139554-45141260~~chr21:45817765-45819179,
chr21:45139554-45141260~~chr21:45819453-45821601,
chr21:45139555-45141248~~chr21:45819512-45821569,
chr21:45139688-45141261~~chr21:45817813-45819059,
chr21:45139688-45141261~~chr21:45819215-45821572,
chr21:45139699-45141285~~chr21:45818578-45821611,
chr21:45139703-45141220~~chr21:45819757-45821509,
chr21:45139731-45141427~~chr21:45818438-45821813,
chr21:45139734-45141308~~chr21:45819513-45821757,
chr21:45139756-45141227~~chr21:45819438-45821567,
chr21:45139777-45141216~~chr21:45818539-45821603,
chr21:45139825-45141312~~chr21:45819878-45821577,
chr21:45150000-45175000~~chr21:45800000-45825000,
chr21:45200000-45225000~~chr21:45800000-45825000,
chr21:45275000-45300000~~chr21:45800000-45825000,
chr21:45291323-45293772~~chr21:45817787-45821574,
chr21:45291491-45294096~~chr21:45818200-45821818,
chr21:45291547-45293953~~chr21:45818438-45821813,
chr21:45291564-45293921~~chr21:45817873-45821737,
chr21:45291571-45293755~~chr21:45818578-45821611,
chr21:45291571-45294131~~chr21:45819046-45821833,
chr21:45291583-45293732~~chr21:45819758-45821568,
chr21:45291592-45293929~~chr21:45819288-45821635,
chr21:45291598-45293774~~chr21:45818539-45821603,
chr21:45291699-45293755~~chr21:45819453-45821601,
chr21:45291702-45294027~~chr21:45819878-45821577,
chr21:45291806-45293737~~chr21:45819512-45821569,
chr21:45291818-45293858~~chr21:45819958-45821534,
chr21:45291920-45293888~~chr21:45819854-45821495,
chr21:45291941-45293676~~chr21:45820016-45821418,
chr21:45300000-45325000~~chr21:45800000-45825000,
chr21:45325000-45350000~~chr21:45800000-45825000,
chr21:45350000-45375000~~chr21:45800000-45825000,
chr21:45425000-45450000~~chr21:45800000-45825000,
chr21:45438105-45440682~~chr21:45818484-45821583,
chr21:45438142-45440624~~chr21:45818578-45821611,
chr21:45438417-45440836~~chr21:45818438-45821813,
chr21:45443201-45445892~~chr21:45817782-45819362,
chr21:45443201-45445892~~chr21:45819577-45821553,
chr21:45443263-45444867~~chr21:45819855-45821550,
chr21:45443298-45445960~~chr21:45819441-45821575,
chr21:45443306-45446030~~chr21:45819676-45821573,
chr21:45443329-45444663~~chr21:45819512-45821569,
chr21:45443393-45444628~~chr21:45818578-45821611,
chr21:45450000-45475000~~chr21:45800000-45825000,
chr21:45477101-45479170~~chr21:45819453-45821601,
chr21:45477119-45480039~~chr21:45818200-45821818,
chr21:45477292-45479145~~chr21:45819438-45821567,
chr21:45477348-45479204~~chr21:45818578-45821611,
chr21:45477360-45479274~~chr21:45818438-45821813,
chr21:45477385-45479624~~chr21:45819513-45821757,
chr21:45477518-45479023~~chr21:45819894-45821572,
chr21:45477532-45479123~~chr21:45819958-45821534,
chr21:45477626-45479192~~chr21:45819992-45821424,
chr21:45525000-45550000~~chr21:45800000-45825000,
chr21:45541155-45542449~~chr21:45817765-45819179,
chr21:45550000-45575000~~chr21:45800000-45825000,
chr21:45554040-45556961~~chr21:45819765-45821570,
chr21:45554054-45556956~~chr21:45819564-45821784,
chr21:45554057-45556932~~chr21:45819425-45821578,
chr21:45554068-45556963~~chr21:45819485-45821586,
chr21:45554081-45557001~~chr21:45818578-45821611,
chr21:45554102-45556956~~chr21:45817765-45819179,
chr21:45554102-45556956~~chr21:45819453-45821601,
chr21:45554116-45557239~~chr21:45818438-45821813,
chr21:45554117-45556938~~chr21:45817776-45821570,
chr21:45554119-45557159~~chr21:45819878-45821577,
chr21:45554143-45556979~~chr21:45819215-45821572,
chr21:45554175-45556950~~chr21:45817789-45819456,
chr21:45554175-45556950~~chr21:45819855-45821550,
chr21:45554175-45557619~~chr21:45818200-45821818,
chr21:45554177-45557278~~chr21:45819574-45821739,
chr21:45554195-45556971~~chr21:45819288-45821635,
chr21:45554202-45556971~~chr21:45817787-45821574,
chr21:45554208-45555627~~chr21:45819441-45821575,
chr21:45554214-45557007~~chr21:45819894-45821572,
chr21:45554223-45557030~~chr21:45818468-45819723,
chr21:45554223-45557030~~chr21:45819958-45821534,
chr21:45554237-45556867~~chr21:45819438-45821567,
chr21:45554245-45556897~~chr21:45819932-45821531,
chr21:45554248-45557000~~chr21:45819512-45821569,
chr21:45554252-45557219~~chr21:45819046-45821833,
chr21:45554270-45556959~~chr21:45818484-45821583,
chr21:45554282-45557370~~chr21:45817873-45821737,
chr21:45554287-45556968~~chr21:45817782-45819362,
chr21:45554287-45556968~~chr21:45819577-45821553,
chr21:45554290-45556966~~chr21:45819479-45821623,
chr21:45554297-45556971~~chr21:45817860-45821572,
chr21:45554297-45557117~~chr21:45817821-45819130,
chr21:45554297-45557117~~chr21:45819992-45821424,
chr21:45554301-45556961~~chr21:45818539-45821603,
chr21:45554301-45556971~~chr21:45818559-45821572,
chr21:45554314-45556966~~chr21:45819601-45821623,
chr21:45554319-45557073~~chr21:45819854-45821495,
chr21:45554322-45556956~~chr21:45817794-45819025,
chr21:45554322-45556956~~chr21:45819758-45821568,
chr21:45554329-45556937~~chr21:45819576-45821583,
chr21:45554331-45556939~~chr21:45818525-45821578,
chr21:45554345-45557074~~chr21:45820016-45821418,
chr21:45554359-45556990~~chr21:45819186-45821572,
chr21:45554362-45557128~~chr21:45819877-45821487,
chr21:45554367-45557069~~chr21:45817841-45819035,
chr21:45554367-45557069~~chr21:45819916-45821488,
chr21:45554407-45556897~~chr21:45819894-45821519,
chr21:45554407-45556976~~chr21:45819554-45821538,
chr21:45554441-45556961~~chr21:45819757-45821509,
chr21:45554476-45556827~~chr21:45820082-45821363,
chr21:45575000-45600000~~chr21:45800000-45825000,
chr21:45640683-45641855~~chr21:45817841-45819035,
chr21:45675000-45700000~~chr21:45800000-45825000,
chr21:45694422-45696402~~chr21:45819564-45821784,
chr21:45694441-45696331~~chr21:45819765-45821570,
chr21:45694513-45696084~~chr21:45819806-45821569,
chr21:45694552-45696040~~chr21:45819886-45821571,
chr21:45694618-45696100~~chr21:45818578-45821540,