- Basic information
- CohesinDB ID: CDBP00421362
- Locus: chr21-45824560-45825827
-
Data sourse: GSE206145, GSE206145-NatGen2015, GSE67783, GSE86191
-
Cell type: RPE, Fibroblast, HCT-116, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: SA1,Rad21,SA2
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
83% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"15_Quies": 44%,
"14_ReprPCWk": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: PGR, SOX2, XBP1, FOXA1, SUZ12, ZFHX2, HDGF, ZNF90, ATF3, THAP1, CTCFL, CHD7, CBFB, PAX5, TP63, MITF, MYOG, JMJD1C, ZNF506, ELF1, TEAD1, TRIM28, NFE2L2, LMO2, ESR1, MLL, USF2, CTCF, JUN, LMO1, E2F6, TRIM24, ZNF528, FOXA3, RBPJ, TFAP2C, GLIS1, JARID2, POU2F2, CHD8, BRD1, MYCN, ZNF263, POU5F1, ID3, CDK7, DUX4, ZSCAN5A, ZBTB48, DDX5, ERG2, ERG, ASCL1, OGG1, ZNF341, ETS1, MYC, SMARCA4, RFX1, RAD21, GRHL3, GABPA, STAT3, XRCC5, APC, PRDM14, RCOR1, DNMT3B, TERF2, ZNF639, ARNTL, NR3C1, CEBPB, SRSF3, KMT2A, CREB1, EZH2, GRHL2, EBF3, GABPB1, SPI1, ZNF257, KLF17, GATA2, MXD3, SIX2, FLI1, MXI1, ATF1, RUNX1, CBX1, SMC1A, CEBPA, NKX2-2, ZNF707, SIRT6, CRY1, ZFX, POU4F2, TET2, ERG3, ZNF770, TWIST1, RARA, ZNF384, NOTCH1, TAF15, RUNX2, ARNT, NRF1, PBX4, ZNF48, PRDM9, NCAPH2, FOS, CHD1, CDK8, KDM6B, MYB, SCRT2, ZNF3, KLF9, NCOA1, SETDB1, USF1, REST, TCF3, GLIS2, AATF, SMC3, STAG1, TRP47, ZNF283, CBFA2T2, FOXA2, AGO1, EBF1, CHD2, CREM, ZNF600, GTF2B, WT1, ZBTB33, CDK9, HOXB13, YY1, RELA, TARDBP, SP140, ZIC2, HIF1A, GATA3, TAL1, MAX, SPIB, ZNF143, HAND2, PLAG1, NCOA3, NR2F1, KDM5B, TP53, ZNF334, EGR2, T, BHLHE40, AR, RXR, ZBTB42, HEXIM1, TFIIIC, HSF1, NCOR1, BRD4, SCRT1, CLOCK, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): FAM207A,ITGB2,CFAP410,PFKL,SLC19A1,TRPM2,PCBP3,ADARB1,COL18A1,POFUT2,ITGB2-AS1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 5
- Number of somatic mutations (non-coding): 5
- Related genes and loops
- Related gene:
ENSG00000141959,
ENSG00000160226,
ENSG00000142185,
ENSG00000160255,
ENSG00000227039,
ENSG00000160256,
ENSG00000197381,
ENSG00000186866,
ENSG00000182871,
ENSG00000173638,
ENSG00000183570,
- Related loop:
chr21:44325000-44350000~~chr21:45825000-45850000,
chr21:44925000-44950000~~chr21:45800000-45825000,
chr21:44950000-44975000~~chr21:45800000-45825000,
chr21:44950000-44975000~~chr21:45825000-45850000,
chr21:44975000-45000000~~chr21:45800000-45825000,
chr21:44975000-45000000~~chr21:45825000-45850000,
chr21:45125000-45150000~~chr21:45800000-45825000,
chr21:45125000-45150000~~chr21:45825000-45850000,
chr21:45136450-45139355~~chr21:45818438-45821813,
chr21:45136469-45139375~~chr21:45817787-45821574,
chr21:45139554-45141260~~chr21:45819453-45821601,
chr21:45139555-45141248~~chr21:45819512-45821569,
chr21:45139688-45141261~~chr21:45819215-45821572,
chr21:45139699-45141285~~chr21:45818578-45821611,
chr21:45139703-45141220~~chr21:45819757-45821509,
chr21:45139731-45141427~~chr21:45818438-45821813,
chr21:45139734-45141308~~chr21:45819513-45821757,
chr21:45139756-45141227~~chr21:45819438-45821567,
chr21:45139777-45141216~~chr21:45818539-45821603,
chr21:45139825-45141312~~chr21:45819878-45821577,
chr21:45150000-45175000~~chr21:45800000-45825000,
chr21:45200000-45225000~~chr21:45800000-45825000,
chr21:45275000-45300000~~chr21:45800000-45825000,
chr21:45275000-45300000~~chr21:45825000-45850000,
chr21:45291323-45293772~~chr21:45817787-45821574,
chr21:45291491-45294096~~chr21:45818200-45821818,
chr21:45291547-45293953~~chr21:45818438-45821813,
chr21:45291564-45293921~~chr21:45817873-45821737,
chr21:45291571-45293755~~chr21:45818578-45821611,
chr21:45291571-45294131~~chr21:45819046-45821833,
chr21:45291583-45293732~~chr21:45819758-45821568,
chr21:45291592-45293929~~chr21:45819288-45821635,
chr21:45291598-45293774~~chr21:45818539-45821603,
chr21:45291699-45293755~~chr21:45819453-45821601,
chr21:45291702-45294027~~chr21:45819878-45821577,
chr21:45291806-45293737~~chr21:45819512-45821569,
chr21:45291818-45293858~~chr21:45819958-45821534,
chr21:45291920-45293888~~chr21:45819854-45821495,
chr21:45291941-45293676~~chr21:45820016-45821418,
chr21:45300000-45325000~~chr21:45800000-45825000,
chr21:45325000-45350000~~chr21:45800000-45825000,
chr21:45350000-45375000~~chr21:45800000-45825000,
chr21:45425000-45450000~~chr21:45800000-45825000,
chr21:45425000-45450000~~chr21:45825000-45850000,
chr21:45438105-45440682~~chr21:45818484-45821583,
chr21:45438142-45440624~~chr21:45818578-45821611,
chr21:45438417-45440836~~chr21:45818438-45821813,
chr21:45443201-45445892~~chr21:45819577-45821553,
chr21:45443263-45444867~~chr21:45819855-45821550,
chr21:45443298-45445960~~chr21:45819441-45821575,
chr21:45443306-45446030~~chr21:45819676-45821573,
chr21:45443329-45444663~~chr21:45819512-45821569,
chr21:45443393-45444628~~chr21:45818578-45821611,
chr21:45450000-45475000~~chr21:45800000-45825000,
chr21:45450000-45475000~~chr21:45825000-45850000,
chr21:45477101-45479170~~chr21:45819453-45821601,
chr21:45477119-45480039~~chr21:45818200-45821818,
chr21:45477292-45479145~~chr21:45819438-45821567,
chr21:45477348-45479204~~chr21:45818578-45821611,
chr21:45477360-45479274~~chr21:45818438-45821813,
chr21:45477385-45479624~~chr21:45819513-45821757,
chr21:45477518-45479023~~chr21:45819894-45821572,
chr21:45477532-45479123~~chr21:45819958-45821534,
chr21:45477626-45479192~~chr21:45819992-45821424,
chr21:45525000-45550000~~chr21:45800000-45825000,
chr21:45550000-45575000~~chr21:45800000-45825000,
chr21:45550000-45575000~~chr21:45825000-45850000,
chr21:45554040-45556961~~chr21:45819765-45821570,
chr21:45554054-45556956~~chr21:45819564-45821784,
chr21:45554057-45556932~~chr21:45819425-45821578,
chr21:45554068-45556963~~chr21:45819485-45821586,
chr21:45554081-45557001~~chr21:45818578-45821611,
chr21:45554102-45556956~~chr21:45819453-45821601,
chr21:45554116-45557239~~chr21:45818438-45821813,
chr21:45554117-45556938~~chr21:45817776-45821570,
chr21:45554119-45557159~~chr21:45819878-45821577,
chr21:45554143-45556979~~chr21:45819215-45821572,
chr21:45554175-45556950~~chr21:45819855-45821550,
chr21:45554175-45557619~~chr21:45818200-45821818,
chr21:45554177-45557278~~chr21:45819574-45821739,
chr21:45554195-45556971~~chr21:45819288-45821635,
chr21:45554202-45556971~~chr21:45817787-45821574,
chr21:45554208-45555627~~chr21:45819441-45821575,
chr21:45554214-45557007~~chr21:45819894-45821572,
chr21:45554223-45557030~~chr21:45818468-45819723,
chr21:45554223-45557030~~chr21:45819958-45821534,
chr21:45554237-45556867~~chr21:45819438-45821567,
chr21:45554245-45556897~~chr21:45819932-45821531,
chr21:45554248-45557000~~chr21:45819512-45821569,
chr21:45554252-45557219~~chr21:45819046-45821833,
chr21:45554270-45556959~~chr21:45818484-45821583,
chr21:45554282-45557370~~chr21:45817873-45821737,
chr21:45554287-45556968~~chr21:45819577-45821553,
chr21:45554290-45556966~~chr21:45819479-45821623,
chr21:45554297-45556971~~chr21:45817860-45821572,
chr21:45554297-45557117~~chr21:45819992-45821424,
chr21:45554301-45556961~~chr21:45818539-45821603,
chr21:45554301-45556971~~chr21:45818559-45821572,
chr21:45554314-45556966~~chr21:45819601-45821623,
chr21:45554319-45557073~~chr21:45819854-45821495,
chr21:45554322-45556956~~chr21:45819758-45821568,
chr21:45554329-45556937~~chr21:45819576-45821583,
chr21:45554331-45556939~~chr21:45818525-45821578,
chr21:45554345-45557074~~chr21:45820016-45821418,
chr21:45554359-45556990~~chr21:45819186-45821572,
chr21:45554362-45557128~~chr21:45819877-45821487,
chr21:45554367-45557069~~chr21:45819916-45821488,
chr21:45554407-45556897~~chr21:45819894-45821519,
chr21:45554407-45556976~~chr21:45819554-45821538,
chr21:45554441-45556961~~chr21:45819757-45821509,
chr21:45554476-45556827~~chr21:45820082-45821363,
chr21:45575000-45600000~~chr21:45800000-45825000,
chr21:45675000-45700000~~chr21:45800000-45825000,
chr21:45694422-45696402~~chr21:45819564-45821784,
chr21:45694441-45696331~~chr21:45819765-45821570,
chr21:45694513-45696084~~chr21:45819806-45821569,
chr21:45694552-45696040~~chr21:45819886-45821571,
chr21:45694618-45696100~~chr21:45818578-45821540,