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Basic information

CohesinDB ID: CDBP00421363

Locus: chr21-45826840-45830627

Data sourse: GSE67783, GSE86191, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE111537, GSE50893

Cell type: RPE, GM2630, Fibroblast, HCT-116, GM12891, K-562, OCI-AML-3, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.911

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 39%, "14_ReprPCWk": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, SOX2, XBP1, FOXA1, SUZ12, ZFHX2, HDGF, ZNF90, ATF3, THAP1, CTCFL, CHD7, CBFB, PAX5, TP63, MITF, MYOG, JMJD1C, ZNF506, ELF1, TEAD1, TRIM28, NFE2L2, LMO2, ESR1, MLL, USF2, CTCF, JUN, LMO1, E2F6, TRIM24, ZNF528, FOXA3, RBPJ, TFAP2C, GLIS1, JARID2, POU2F2, CHD8, BRD1, MYCN, ZNF263, POU5F1, ID3, CDK7, DUX4, ZSCAN5A, ZBTB48, DDX5, ERG2, ERG, ASCL1, OGG1, ZNF341, ETS1, MYC, SMARCA4, RFX1, RAD21, GRHL3, GABPA, STAT3, XRCC5, APC, PRDM14, RCOR1, DNMT3B, TERF2, ZNF639, ARNTL, NR3C1, CEBPB, SRSF3, KMT2A, CREB1, EZH2, GRHL2, EBF3, GABPB1, SPI1, ZNF257, KLF17, GATA2, MXD3, SIX2, FLI1, MXI1, ATF1, RUNX1, CBX1, SMC1A, CEBPA, NKX2-2, ZNF707, SIRT6, CRY1, ZFX, POU4F2, TET2, ERG3, ZNF770, TWIST1, RARA, ZNF384, NOTCH1, TAF15, RUNX2, ARNT, NRF1, PBX4, ZNF48, PRDM9, NCAPH2, FOS, CHD1, CDK8, KDM6B, MYB, SCRT2, ZNF3, KLF9, NCOA1, SETDB1, USF1, REST, TCF3, GLIS2, AATF, SMC3, STAG1, TRP47, ZNF283, CBFA2T2, FOXA2, AGO1, EBF1, CHD2, CREM, ZNF600, GTF2B, WT1, ZBTB33, CDK9, HOXB13, YY1, RELA, TARDBP, SP140, ZIC2, HIF1A, GATA3, TAL1, MAX, SPIB, ZNF143, HAND2, PLAG1, NCOA3, NR2F1, KDM5B, TP53, ZNF334, EGR2, T, BHLHE40, AR, RXR, ZBTB42, HEXIM1, TFIIIC, HSF1, NCOR1, BRD4, SCRT1, CLOCK, MAZ, AHR

Target gene symbol (double-evidenced CRMs): SLC19A1,CFAP410,COL18A1,ADARB1,TRPM2,PFKL,POFUT2,PCBP3,FAM207A

Function elements

Human SNPs: .

Number of somatic mutations (coding): 29

Number of somatic mutations (non-coding): 6

Related genes and loops

Related gene: ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000160256, ENSG00000197381, ENSG00000186866, ENSG00000182871, ENSG00000173638, ENSG00000183570,

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Deatailed information for cohesin site CDBP00421363