- Basic information
- CohesinDB ID: CDBP00421366
- Locus: chr21-45833478-45836709
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Data sourse: GSE67783, GSE86191, GSE111913, GSE206145, GSE206145-NatGen2015, ENCSR153HNT
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Cell type: RPE, Fibroblast, HCT-116, RT-112, K-562, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: SA1,Rad21,SA2,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
83% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 39%,
"7_Enh": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, SOX2, XBP1, FOXA1, SUZ12, ZFHX2, HDGF, ZNF90, ATF3, THAP1, CTCFL, CHD7, CBFB, PAX5, TP63, MITF, MYOG, JMJD1C, ZNF506, ELF1, TEAD1, TRIM28, NFE2L2, LMO2, ESR1, MLL, USF2, CTCF, JUN, LMO1, E2F6, TRIM24, ZNF528, FOXA3, RBPJ, TFAP2C, GLIS1, JARID2, POU2F2, CHD8, BRD1, MYCN, ZNF263, POU5F1, ID3, CDK7, DUX4, ZSCAN5A, ZBTB48, DDX5, ERG2, ERG, ASCL1, OGG1, ZNF341, ETS1, MYC, SMARCA4, RFX1, RAD21, GRHL3, GABPA, STAT3, XRCC5, APC, PRDM14, RCOR1, DNMT3B, TERF2, ZNF639, ARNTL, NR3C1, CEBPB, SRSF3, KMT2A, CREB1, EZH2, GRHL2, EBF3, GABPB1, SPI1, ZNF257, KLF17, GATA2, MXD3, SIX2, FLI1, MXI1, ATF1, RUNX1, CBX1, SMC1A, CEBPA, NKX2-2, ZNF707, SIRT6, CRY1, ZFX, POU4F2, TET2, ERG3, ZNF770, TWIST1, RARA, ZNF384, NOTCH1, TAF15, RUNX2, ARNT, NRF1, PBX4, ZNF48, PRDM9, NCAPH2, FOS, CHD1, CDK8, KDM6B, MYB, SCRT2, ZNF3, KLF9, NCOA1, SETDB1, USF1, REST, TCF3, GLIS2, AATF, SMC3, STAG1, TRP47, ZNF283, CBFA2T2, FOXA2, AGO1, EBF1, CHD2, CREM, ZNF600, GTF2B, WT1, ZBTB33, CDK9, HOXB13, YY1, RELA, TARDBP, SP140, ZIC2, HIF1A, GATA3, TAL1, MAX, SPIB, ZNF143, HAND2, PLAG1, NCOA3, NR2F1, KDM5B, TP53, ZNF334, EGR2, T, BHLHE40, AR, RXR, ZBTB42, HEXIM1, TFIIIC, HSF1, NCOR1, BRD4, SCRT1, CLOCK, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): CFAP410,FAM207A,TRPM2,PCBP3,SLC19A1,POFUT2,PFKL,ADARB1,COL18A1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 23
- Number of somatic mutations (non-coding): 4
- Related genes and loops
- Related gene:
ENSG00000141959,
ENSG00000160226,
ENSG00000142185,
ENSG00000160256,
ENSG00000197381,
ENSG00000186866,
ENSG00000182871,
ENSG00000173638,
ENSG00000183570,
- Related loop:
chr21:44325000-44350000~~chr21:45825000-45850000,
chr21:44950000-44975000~~chr21:45825000-45850000,
chr21:44975000-45000000~~chr21:45825000-45850000,
chr21:45125000-45150000~~chr21:45825000-45850000,
chr21:45275000-45300000~~chr21:45825000-45850000,
chr21:45425000-45450000~~chr21:45825000-45850000,
chr21:45450000-45475000~~chr21:45825000-45850000,
chr21:45550000-45575000~~chr21:45825000-45850000,