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Basic information

CohesinDB ID: CDBP00421368

Locus: chr21-45844115-45844699

Data sourse: GSE206145-NatGen2015, GSE67783, GSE86191

Cell type: Fibroblast, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 58%, "14_ReprPCWk": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, TRP47, POU2F2, CHD8, CEBPA, MYCN, ZNF263, POU5F1, CRY1, ZFX, RUNX1T1, TBL1X, POU4F2, ZBTB48, WT1, TET2, ERG3, CDK9, YY1, RELA, TAF15, ATF3, MYC, SP140, ARNT, HIF1A, KLF15, ETV6, CEBPG, CEBPB, TEAD3, NR2F1, STAG1, ESR1, SETDB1, CTCF, AR, HSF1, ZBTB26, HNRNPLL, SMC3, BRCA1, PTBP1, AHR

Target gene symbol (double-evidenced CRMs): PCBP3,PFKL,FAM207A,POFUT2,TRPM2,SLC19A1,CFAP410,ADARB1,COL18A1

Function elements

Human SNPs: Core_binding_factor_acute_myeloid_leukemia

Number of somatic mutations (coding): 4

Number of somatic mutations (non-coding): 4

Related genes and loops

Related gene: ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000160256, ENSG00000197381, ENSG00000186866, ENSG00000182871, ENSG00000173638, ENSG00000183570,

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Deatailed information for cohesin site CDBP00421368