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Basic information

CohesinDB ID: CDBP00421371

Locus: chr21-45847320-45849116

Data sourse: GSE206145-GSE177045, GSE72082, ENCSR000BSB, ENCSR000BLY, GSE131606, GSE25021, ENCSR000EDW, GSE115602, ENCSR000BTU, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE112028, ENCSR703TNG, GSE116344, ENCSR000EEG, ENCSR000BLS, ENCSR000EHX, ENCSR000BTQ, ENCSR167MTG, GSE110061, GSE129526, ENCSR054FKH, ENCSR000EDE, GSE68388, GSE83726, GSE126990, ENCSR000ECS

Cell type: MCF-7, Hela-Kyoto, HCT-116, RH4, Hep-G2, Ishikawa, HeLa-S3, SK-N-SH, K-562, HeLa-Tet-On, HuCC-T1, DKO

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 12% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.867

Subunit: SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 44%, "14_ReprPCWk": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, SOX2, NME2, XBP1, FOXA1, SUZ12, HDGF, PRDM1, ZNF444, PAX5, ZSCAN4, MITF, CDX2, ELF1, ZNF573, ETV1, SNAI2, LMO2, ESR1, USF2, CTCF, EP300, BAF155, MNT, LMO1, DPF2, IRF4, RFX5, E2F1, TEAD4, RBPJ, TFAP2C, NANOG, ZNF263, MYCN, TOP2A, POU5F1, MTA2, ZBTB48, ERG, MYC, SMARCA4, RAD21, GRHL3, BATF3, GABPA, STAT3, NKX3-1, IKZF1, DNMT3B, NR3C1, CEBPB, CREB1, EZH2, GRHL2, SPI1, SSRP1, GATA2, SIX2, ZIM3, RUNX1, SMC1A, MAFG, EZH2phosphoT487, CRY1, SOX13, ZFX, ZNF18, ZNF384, NOTCH1, GR, ARNT, MED1, MYB, SCRT2, PIAS1, C11orf30, MAFK, HNF4A, ATF7, HNRNPLL, MLLT1, STAG1, PPARG, ZNF600, WT1, MAFF, MEF2C, CDK9, HOXB13, YY1, RELA, ZNF19, TARDBP, JUNB, SP140, HIF1A, GATA3, TAL1, MAX, ZNF143, CBX2, PLAG1, TCF7L2, NEUROG2, KDM5B, PKNOX1, ELF3, BHLHE40, AR, PAX3-FOXO1, EGLN2, IKZF2, BRD4, SCRT1, MAZ, ZNF316

Target gene symbol (double-evidenced CRMs): PCBP3,PFKL,FAM207A,SLC19A1,CFAP410,POFUT2,ADARB1,TRPM2,COL18A1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 12

Number of somatic mutations (non-coding): 6

Related genes and loops

Related gene: ENSG00000141959, ENSG00000160226, ENSG00000142185, ENSG00000160256, ENSG00000197381, ENSG00000186866, ENSG00000182871, ENSG00000173638, ENSG00000183570,

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Deatailed information for cohesin site CDBP00421371