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Basic information

CohesinDB ID: CDBP00421373

Locus: chr21-45852961-45853362

Data sourse: GSE67783, GSE86191

Cell type: HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: SA1,Rad21

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 52%, "14_ReprPCWk": 24%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: XBP1, FOXA1, SUZ12, ZFHX2, TFAP4, ATF3, PRDM1, MORC2, TP63, TRIM28, ESR1, OCA2, TP73, CTCF, JUN, GATA6, TEAD4, JARID2, POU2F2, CHD8, BRD1, MYCN, POU5F1, ZNF317, ZBTB48, STAT1, ERG2, ZNF300, ERG, ASCL1, OGG1, MYC, GRHL3, PROX1, APC, DNMT3B, CEBPB, EZH2, GRHL2, SPI1, HCFC1R1, RUNX1, CEBPA, EZH2phosphoT487, ZFX, POU4F2, TET2, ERG3, RUNX2, GATA4, ARNT, CHD1, FOS, REST, ZNF548, AATF, SMC3, STAG1, TRP47, ZNF316, ZNF600, MAFF, WT1, MEF2C, YY1, RELA, TARDBP, SP140, ZIC2, HIF1A, MAX, PLAG1, CEBPG, NCOA3, NEUROG2, NR2F1, TP53, ZNF334, EGR2, AR, ZNF366, HSF1, BRD4, MAZ, AHR

Target gene symbol (double-evidenced CRMs): ITGB2-AS1,PCBP3,FAM207A,COL18A1,ITGB2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 15

Number of somatic mutations (non-coding): 3

Related genes and loops

Related gene: ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000182871, ENSG00000183570,

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Deatailed information for cohesin site CDBP00421373