Deatailed information for cohesin site CDBP00421379

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  • Basic information
  • CohesinDB ID: CDBP00421379
  • Locus: chr21-45867090-45872210
  • Data sourse: ENCSR000EFJ, GSE206145-GSE177045, GSE67783, GSE86191, GSE115602, ENCSR000BLY, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE25021, GSE165895
  • Cell type: MCF-7, RPE, Fibroblast, HCT-116, IMR-90, SK-N-SH, K-562, HSPC, HFFc6
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 8% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.900
  • Subunit: SA1,Rad21,SMC1,SA2,Mau2
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS,TES
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 83% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 31%, "14_ReprPCWk": 20%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOSL1, PGR, TRIM25, E2F7, XBP1, FOXA1, HLF, SUZ12, UBTF, ZNF90, ATF3, NFIC, ZFP64, CTCFL, CHD7, CBFB, PAX5, TP63, ZNF467, KLF5, TEAD1, TRIM28, ELF1, SNAI2, ESR1, OCA2, TP73, MED26, USF2, CTCF, JUN, TCF12, EP300, KLF1, LMO1, GATA6, SOX4, E2F6, PRKDC, E2F1, TEAD4, GTF2F1, TFAP2C, GLIS1, POU2F2, BRD1, MYCN, ZNF263, TOP2A, CDK7, ZNF317, ZBTB48, ZSCAN5A, STAT1, DUX4, HOXC5, ERG, PBX1, ASCL1, OGG1, ZNF341, ETS1, MYC, SMARCA4, RAD21, LHX2, GRHL3, RXRA, GABPA, STAT3, PRDM14, RCOR1, DNMT3B, VDR, NR3C1, CEBPB, EZH2, GRHL2, GABPB1, ZHX2, SPI1, KLF17, GATA2, FLI1, ZNF284, MRTFB, NCOA2, HCFC1R1, ETV5, RUNX1, BCL6, SMC1A, CEBPA, EZH2phosphoT487, SIN3A, ZFX, SMAD3, TET2, CBX8, ERG3, SMARCC1, TWIST1, ZNF18, CREBBP, ZNF384, TAF15, RUNX2, GATA4, ZNF184, NRF1, ARNT, ZNF48, PRDM9, PBX3, FOXM1, FOS, CHD1, MED1, TEAD3, KDM6B, MYB, SUPT16H, USF1, NIPBL, TFAP2A, IKZF5, REST, POU2F3, HNRNPLL, CTBP2, MBD2, TCF3, AATF, STAG1, TRP47, FOXA2, AGO1, EBF1, ZNF600, GTF2B, WT1, ZNF662, ZBTB33, CDK9, HOXB13, ZKSCAN1, FOXO3, KDM1A, YY1, RELA, JUNB, BRG1, SP140, ZIC2, HIF1A, OTX2, GATA3, BATF, TAL1, MAX, NRIP1, GATA1, ZNF143, HAND2, CBX2, PLAG1, KLF4, TLE3, NCOA3, TCF7L2, NR2F1, KDM5B, TP53, ZNF334, NFKB1, ZSCAN22, BRD2, BHLHE40, AR, ZNF445, TAF1, YAP1, RXR, HEXIM1, EGR1, TFIIIC, HSF1, NCOR1, ZBTB26, BRD4, JUND, MAZ, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): PCBP3,ITGB2,FAM207A,COL18A1,ITGB2-AS1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 210
  • Number of somatic mutations (non-coding): 33
  • Related genes and loops
  • Related gene: ENSG00000160255, ENSG00000227039, ENSG00000160256, ENSG00000182871, ENSG00000183570,
  • Related loop: chr21:44925000-44950000~~chr21:45850000-45875000, chr21:45125000-45150000~~chr21:45875000-45900000, chr21:45325000-45350000~~chr21:45875000-45900000, chr21:45450000-45475000~~chr21:45850000-45875000, chr21:45550000-45575000~~chr21:45875000-45900000, chr21:45675000-45700000~~chr21:45875000-45900000, chr21:45725000-45750000~~chr21:45875000-45900000, chr21:45750000-45775000~~chr21:45875000-45900000, chr21:45875000-45900000~~chr21:46050000-46075000,
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