- Basic information
- CohesinDB ID: CDBP00421382
- Locus: chr21-45874401-45877128
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Data sourse: ENCSR000BLD, GSE72082, ENCSR000BLY, GSE111537, GSE131606, GSE25021, GSE165895, ENCSR000EFJ, GSE67783, GSE86191, GSE206145-NatGen2015, GSE130135, GSE116344, GSE106870, GSE118494, GSE76815, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR000EHX, GSE131956, ENCSR000HPG, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726
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Cell type: RH4, CVI-hiPSC, HuCC-T1, RPE, Fibroblast, IMR-90, K-562, HFFc6, DKO, H1-hESC, GBM39, SK-N-SH, RT-112, MCF-7, HCT-116, HEK293T, Hep-G2, OCI-AML-3, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 12% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.789
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
83% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 25%,
"7_Enh": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, PGR, TRIM25, E2F7, XBP1, FOXA1, HLF, SUZ12, UBTF, ZNF90, ATF3, NFIC, ZFP64, CTCFL, CHD7, CBFB, PAX5, TP63, ZNF467, KLF5, TEAD1, TRIM28, ELF1, SNAI2, ESR1, OCA2, TP73, MED26, USF2, CTCF, JUN, TCF12, EP300, KLF1, LMO1, GATA6, SOX4, E2F6, PRKDC, E2F1, TEAD4, GTF2F1, TFAP2C, GLIS1, POU2F2, BRD1, MYCN, ZNF263, TOP2A, CDK7, ZNF317, ZBTB48, ZSCAN5A, STAT1, DUX4, HOXC5, ERG, PBX1, ASCL1, OGG1, ZNF341, ETS1, MYC, SMARCA4, RAD21, LHX2, GRHL3, RXRA, GABPA, STAT3, PRDM14, RCOR1, DNMT3B, VDR, NR3C1, CEBPB, EZH2, GRHL2, GABPB1, ZHX2, SPI1, KLF17, GATA2, FLI1, ZNF284, MRTFB, NCOA2, HCFC1R1, ETV5, RUNX1, BCL6, SMC1A, CEBPA, EZH2phosphoT487, SIN3A, ZFX, SMAD3, TET2, CBX8, ERG3, SMARCC1, TWIST1, ZNF18, CREBBP, ZNF384, TAF15, RUNX2, GATA4, ZNF184, NRF1, ARNT, ZNF48, PRDM9, PBX3, FOXM1, FOS, CHD1, MED1, TEAD3, KDM6B, MYB, SUPT16H, USF1, NIPBL, TFAP2A, IKZF5, REST, POU2F3, HNRNPLL, CTBP2, MBD2, TCF3, AATF, STAG1, TRP47, FOXA2, AGO1, EBF1, ZNF600, GTF2B, WT1, ZNF662, ZBTB33, CDK9, HOXB13, ZKSCAN1, FOXO3, KDM1A, YY1, RELA, JUNB, BRG1, SP140, ZIC2, HIF1A, OTX2, GATA3, BATF, TAL1, MAX, NRIP1, GATA1, ZNF143, HAND2, CBX2, PLAG1, KLF4, TLE3, NCOA3, TCF7L2, NR2F1, KDM5B, TP53, ZNF334, NFKB1, ZSCAN22, BRD2, BHLHE40, AR, ZNF445, TAF1, YAP1, RXR, HEXIM1, EGR1, TFIIIC, HSF1, NCOR1, ZBTB26, BRD4, JUND, MAZ, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): COL18A1,ITGB2-AS1,PCBP3,ADARB1,SLC19A1,ITGB2,FAM207A
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 120
- Number of somatic mutations (non-coding): 24
- Related genes and loops
- Related gene:
ENSG00000160255,
ENSG00000227039,
ENSG00000160256,
ENSG00000197381,
ENSG00000182871,
ENSG00000173638,
ENSG00000183570,
- Related loop:
chr21:44925000-44950000~~chr21:45850000-45875000,
chr21:45125000-45150000~~chr21:45875000-45900000,
chr21:45139624-45141292~~chr21:45879491-45881481,
chr21:45139756-45141227~~chr21:45879726-45881542,
chr21:45139859-45141236~~chr21:45879927-45881351,
chr21:45291923-45293716~~chr21:45879919-45881338,
chr21:45325000-45350000~~chr21:45875000-45900000,
chr21:45450000-45475000~~chr21:45850000-45875000,
chr21:45477101-45479170~~chr21:45879575-45881506,
chr21:45550000-45575000~~chr21:45875000-45900000,
chr21:45554102-45556956~~chr21:45879575-45881506,
chr21:45554116-45557239~~chr21:45879498-45881495,
chr21:45554177-45557278~~chr21:45879491-45881481,
chr21:45554270-45556959~~chr21:45879684-45881506,
chr21:45554301-45556961~~chr21:45879697-45881735,
chr21:45554337-45556942~~chr21:45879710-45881470,
chr21:45554367-45557069~~chr21:45879927-45881351,
chr21:45675000-45700000~~chr21:45875000-45900000,
chr21:45694441-45696331~~chr21:45879486-45881477,
chr21:45725000-45750000~~chr21:45875000-45900000,
chr21:45750000-45775000~~chr21:45875000-45900000,
chr21:45846155-45847509~~chr21:45879483-45881988,
chr21:45847135-45849106~~chr21:45879481-45881522,
chr21:45847189-45849001~~chr21:45879514-45881583,
chr21:45847196-45848957~~chr21:45879671-45881548,
chr21:45847206-45849095~~chr21:45879694-45881570,
chr21:45875000-45900000~~chr21:46050000-46075000,
chr21:45879775-45881500~~chr21:45922251-45924201,