- Basic information
- CohesinDB ID: CDBP00421383
- Locus: chr21-45877568-45881967
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Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE38411, ENCSR000BLD, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
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Cell type: MDM, RH4, GM10847, GM2610, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, HEKn, Ishikawa, Kelly, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, THP-1, HEK293T, Hep-G2, A-549, HUVEC, HCAEC, GM19238, HeLa, TC-71, Neutrophil, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 61% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.267
- Subunit: SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: TES,Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
83% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"7_Enh": 27%,
"5_TxWk": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, KDM3A, IKZF3, PAX5, TEAD1, ZNF121, OCA2, MED26, PITX3, HDAC8, SOX5, E2F4, GATAD2A, JARID2, BRD3, ZNF263, POU5F1, TOP2A, CTBP1, DUX4, STAT1, ZNF563, SAP130, ERG, PAX6, SMARCA4, RFX1, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, KLF17, ZNF257, GATA2, ZNF644, MXD3, SIX2, FLI1, DRAP1, MXI1, HCFC1R1, RUNX1, CEBPA, HDAC1, TET2, ZNF654, SP5, TRIM22, SMARCC1, ZNF549, ZBTB2, FOXM1, SMARCB1, PIAS1, SMAD1, MBD1, STAT5A, IKZF5, MBD2, ELL2, ETV4, CBFA2T2, CBX3, CREM, CHD2, WT1, MEF2C, JUNB, NEUROD1, PLAG1, ZFP69B, ZBTB6, EGR2, ELF3, ARID4B, RXR, EGLN2, HSF1, ZBTB26, SCRT1, FOSL1, XBP1, KDM4B, PBX2, ATF3, ZC3H8, ZFP64, CBFB, TP63, MITF, JMJD1C, ELF1, RBM39, SNAI2, CTCF, JUN, MNT, DPF2, IRF4, RBPJ, TFAP2C, ZBTB48, SRF, NBN, CHD4, HOMEZ, FOXP2, RXRA, NKX3-1, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, KMT2A, GRHL2, ZNF565, EBF3, THAP11, EZH2phosphoT487, AFF4, SOX13, POU4F2, ZNF770, ZNF18, DAXX, BACH1, ARNT, ZNF48, PRDM9, PBX3, NCAPH2, HMGXB4, TEAD3, DIDO1, U2AF1, KLF9, ZBTB18, TBX5, USF1, BCL11A, TFAP2A, GLIS2, SMC3, STAG1, MLLT1, TRP47, MTA3, EBF1, ZNF580, ZKSCAN1, KDM1A, BRG1, ISL1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, MTA1, CBX2, TP53, ZNF334, NFKB1, BRD2, PHF5A, KAT8, RB1, TFIIIC, RNF2, BRD4, JUND, CUX1, TBX2, PGR, SOX2, UBTF, TFAP4, BMI1, CHD7, ZNF444, KLF6, NFE2L2, ESR1, TP73, KLF1, SOX4, E2F6, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, ERG2, HIC1, HOXC5, OGG1, ETS1, MYC, NKX2-1, GABPA, STAT3, DNMT3B, SRSF3, EZH2, ZNF652, MRTFA, SPI1, HDAC2, GATAD2B, NCOA2, ETV5, BCL6, SIN3A, ERG3, MEF2A, RARA, ZNF384, CREBBP, SMAD4, CDK8, ZEB1, SREBF2, MAFK, HNF4A, REST, ARID1A, HNRNPLL, BCOR, AATF, PPARG, TBL1X, GTF2B, RELA, TARDBP, SKIL, MAX, BAP1, TCF7L2, NEUROG2, KDM5B, NR2F1, MYOD1, AR, ZNF324, HEXIM1, DMAP1, AHR, FOSL2, HMG20A, E2F7, HMGN3, SUZ12, RBFOX2, ZFHX2, SFMBT1, ZNF90, NFIC, CTCFL, ZNF629, KLF5, TRIM28, ETV1, USF2, TCF12, EP300, BAF155, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, CHD8, MYCN, SRC, CDK7, ID3, GATAD1, ASCL1, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF667, ARNTL, TFE3, ZGPAT, MRTFB, MYF5, ATF1, PTBP1, SMC1A, CBX1, ZFX, ZNF534, SMAD3, TWIST1, NOTCH1, RUNX2, CDK6, NRF1, CHD1, FOS, MED1, KDM6B, MYB, VEZF1, L3MBTL2, HIF2A, ZBTB7A, CCNT2, TCF3, SKI, PAX7, FOXA2, ZNF600, MIER2, ZBTB33, CDK9, HOXB13, YY1, SP140, HIF1A, OTX2, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF687, BHLHE40, NFKBIZ, TAF1, ZBTB42, CLOCK, MAZ
- Target gene symbol (double-evidenced CRMs): ADARB1,COL18A1,SLC19A1,POFUT2,PCBP3
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 100
- Number of somatic mutations (non-coding): 4
- Related genes and loops
- Related gene:
ENSG00000197381,
ENSG00000186866,
ENSG00000182871,
ENSG00000173638,
ENSG00000183570,
- Related loop:
chr21:44925000-44950000~~chr21:45850000-45875000,
chr21:45125000-45150000~~chr21:45875000-45900000,
chr21:45139624-45141292~~chr21:45879491-45881481,
chr21:45139756-45141227~~chr21:45879726-45881542,
chr21:45139859-45141236~~chr21:45879927-45881351,
chr21:45291923-45293716~~chr21:45879919-45881338,
chr21:45325000-45350000~~chr21:45875000-45900000,
chr21:45450000-45475000~~chr21:45850000-45875000,
chr21:45477101-45479170~~chr21:45879575-45881506,
chr21:45550000-45575000~~chr21:45875000-45900000,
chr21:45554102-45556956~~chr21:45879575-45881506,
chr21:45554116-45557239~~chr21:45879498-45881495,
chr21:45554177-45557278~~chr21:45879491-45881481,
chr21:45554270-45556959~~chr21:45879684-45881506,
chr21:45554301-45556961~~chr21:45879697-45881735,
chr21:45554337-45556942~~chr21:45879710-45881470,
chr21:45554367-45557069~~chr21:45879927-45881351,
chr21:45675000-45700000~~chr21:45875000-45900000,
chr21:45694441-45696331~~chr21:45879486-45881477,
chr21:45725000-45750000~~chr21:45875000-45900000,
chr21:45750000-45775000~~chr21:45875000-45900000,
chr21:45846155-45847509~~chr21:45879483-45881988,
chr21:45847135-45849106~~chr21:45879481-45881522,
chr21:45847189-45849001~~chr21:45879514-45881583,
chr21:45847196-45848957~~chr21:45879671-45881548,
chr21:45847206-45849095~~chr21:45879694-45881570,
chr21:45875000-45900000~~chr21:46050000-46075000,
chr21:45879775-45881500~~chr21:45922251-45924201,