- Basic information
- CohesinDB ID: CDBP00421385
- Locus: chr21-45885857-45888701
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Data sourse: GSE206145-GSE177045, GSE67783, GSE86191, GSE116868, GSE111913, ENCSR000BLY, ENCSR000EHW, GSE206145-NatGen2015, GSE206145, GSE50893, ENCSR153HNT, ENCSR000EHX, GSE68388, GSE83726, GSE111537, GSE116344
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Cell type: MCF-7, GM2630, RPE, Fibroblast, HCT-116, RH4, MB157, RT-112, SK-N-SH, K-562, OCI-AML-3, HSPC, HuCC-T1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 5% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.856
- Subunit: SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: TSS
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
83% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"7_Enh": 31%,
"5_TxWk": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, TRIM25, SOX2, NME2, XBP1, KDM4B, FOXA1, SUZ12, PBX2, UBTF, ZFHX2, ZNF596, HDGF, ATF3, ZNF362, ZBTB5, CHD7, ATF4, CBFB, PAX5, TP63, MITF, ZNF736, ZNF467, JMJD1C, ZNF629, KLF5, ELF1, TRIM28, MAF, ETV1, KLF6, SNAI2, NFE2L2, LMO2, ESR1, MLL, PITX3, CTCF, TCF12, JUN, BAF155, EP300, KLF1, MNT, LMO1, DPF2, SOX4, IRF4, E2F4, RAD51, E2F1, ZNF528, KMT2B, PRDM14, TFAP2C, RBPJ, EED, GLIS1, CHD8, BRD1, ZSCAN5D, MYCN, ZNF263, POU5F1, TOP2A, CTBP1, ZNF317, ZBTB48, ZSCAN5A, STAT1, ERG2, SP4, ERG, ZBTB21, ASCL1, OGG1, MYC, SMARCA4, RAD21, GRHL3, RXRA, GABPA, STAT3, APC, ZNF8, NKX3-1, ZNF398, IKZF1, RCOR1, DNMT3B, NR2F6, NFE2, ARNTL, VDR, NR3C1, CEBPB, SRSF3, ESRRA, KMT2A, CREB1, EZH2, GRHL2, EBF3, NFE2L1, GABPB1, ZHX2, SPI1, IRF1, KLF17, HDAC2, GATA2, MXD3, FLI1, MXI1, NR2C2, SMARCA5, HCFC1R1, MYF5, RUNX1, BCL6, SMC1A, CEBPA, SIRT6, EZH2phosphoT487, MAFG, SIN3A, ZFX, ZBTB12, TET2, ERG3, ZNF770, TWIST1, CREBBP, ZNF384, NOTCH1, RUNX2, CDK6, GATA4, NRF1, ARNT, NFIB, ATF2, ZNF48, PBX3, NR2C1, FOS, SMARCB1, CHD1, MED1, KDM6B, MYB, SCRT2, PIAS1, ZNF3, KLF9, C11orf30, L3MBTL2, TBX5, EVI1, MAFK, BCL11A, USF1, REST, ARID1A, ATF7, ASH2L, ZNF605, HNRNPLL, TCF3, GLIS2, AATF, SMC3, NCOR2, STAG1, TRP47, CBFA2T2, FOXA2, TBL1X, EBF1, CHD2, BRF2, NFATC1, ZNF600, MTA3, MAFF, WT1, MEF2C, CDK9, HOXB13, BCL3, KDM1A, YY1, RELA, NEUROD1, AHR, ZNF148, BRG1, MCM3, SP140, TCF4, HIF1A, ZIC2, ZFP36, GATA3, ZNF519, BATF, TAL1, MAX, SPIB, ZNF143, GATA1, NRIP1, HAND2, PLAG1, TLE3, CEBPG, BCL11B, KLF4, CBX2, NR2F2, NEUROG2, NR2F1, KDM5B, TP53, ZBTB6, ZNF334, NFKB1, MYOD1, EGR2, ELF3, TBX21, BHLHE40, AR, TAF1, RXR, EGLN2, ZNF366, EGR1, HEXIM1, HSF1, NCOR1, BRD4, SCRT1, JUND, MAZ, TBX2, ZNF316, FOSL2
- Target gene symbol (double-evidenced CRMs): PCBP3,SLC19A1,ADARB1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 160
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000197381,
ENSG00000173638,
ENSG00000183570,
- Related loop:
chr21:45125000-45150000~~chr21:45875000-45900000,
chr21:45139624-45141292~~chr21:45879491-45881481,
chr21:45139756-45141227~~chr21:45879726-45881542,
chr21:45139859-45141236~~chr21:45879927-45881351,
chr21:45291923-45293716~~chr21:45879919-45881338,
chr21:45325000-45350000~~chr21:45875000-45900000,
chr21:45477101-45479170~~chr21:45879575-45881506,
chr21:45550000-45575000~~chr21:45875000-45900000,
chr21:45554102-45556956~~chr21:45879575-45881506,
chr21:45554116-45557239~~chr21:45879498-45881495,
chr21:45554177-45557278~~chr21:45879491-45881481,
chr21:45554270-45556959~~chr21:45879684-45881506,
chr21:45554301-45556961~~chr21:45879697-45881735,
chr21:45554337-45556942~~chr21:45879710-45881470,
chr21:45554367-45557069~~chr21:45879927-45881351,
chr21:45675000-45700000~~chr21:45875000-45900000,
chr21:45694441-45696331~~chr21:45879486-45881477,
chr21:45725000-45750000~~chr21:45875000-45900000,
chr21:45750000-45775000~~chr21:45875000-45900000,
chr21:45846155-45847509~~chr21:45879483-45881988,
chr21:45847135-45849106~~chr21:45879481-45881522,
chr21:45847189-45849001~~chr21:45879514-45881583,
chr21:45847196-45848957~~chr21:45879671-45881548,
chr21:45847206-45849095~~chr21:45879694-45881570,
chr21:45875000-45900000~~chr21:46050000-46075000,
chr21:45879775-45881500~~chr21:45922251-45924201,