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Basic information

CohesinDB ID: CDBP00421388

Locus: chr21-45895276-45902934

Data sourse: GSE67783, GSE86191, GSE98367, GSE111913, GSE206145, GSE206145-NatGen2015, GSE120943, ENCSR153HNT, GSE68388

Cell type: RPE, Macrophage, Fibroblast, HCT-116, Monocytes, RT-112, K-562, HSPC, HuCC-T1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.900

Subunit: SA1,Rad21,SA2,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 28%, "14_ReprPCWk": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, TRIM25, SOX2, NME2, XBP1, KDM4B, FOXA1, SUZ12, PBX2, UBTF, ZFHX2, ZNF596, HDGF, ATF3, ZNF362, ZBTB5, CHD7, ATF4, CBFB, PAX5, TP63, MITF, ZNF736, ZNF467, JMJD1C, ZNF629, KLF5, ELF1, TRIM28, MAF, ETV1, KLF6, SNAI2, NFE2L2, LMO2, ESR1, MLL, PITX3, CTCF, TCF12, JUN, BAF155, EP300, KLF1, MNT, LMO1, DPF2, SOX4, IRF4, E2F4, RAD51, E2F1, ZNF528, KMT2B, PRDM14, TFAP2C, RBPJ, EED, GLIS1, CHD8, BRD1, ZSCAN5D, MYCN, ZNF263, POU5F1, TOP2A, CTBP1, ZNF317, ZBTB48, ZSCAN5A, STAT1, ERG2, SP4, ERG, ZBTB21, ASCL1, OGG1, MYC, SMARCA4, RAD21, GRHL3, RXRA, GABPA, STAT3, APC, ZNF8, NKX3-1, ZNF398, IKZF1, RCOR1, DNMT3B, NR2F6, NFE2, ARNTL, VDR, NR3C1, CEBPB, SRSF3, ESRRA, KMT2A, CREB1, EZH2, GRHL2, EBF3, NFE2L1, GABPB1, ZHX2, SPI1, IRF1, KLF17, HDAC2, GATA2, MXD3, FLI1, MXI1, NR2C2, SMARCA5, HCFC1R1, MYF5, RUNX1, BCL6, SMC1A, CEBPA, SIRT6, EZH2phosphoT487, MAFG, SIN3A, ZFX, ZBTB12, TET2, ERG3, ZNF770, TWIST1, CREBBP, ZNF384, NOTCH1, RUNX2, CDK6, GATA4, NRF1, ARNT, NFIB, ATF2, ZNF48, PBX3, NR2C1, FOS, SMARCB1, CHD1, MED1, KDM6B, MYB, SCRT2, PIAS1, ZNF3, KLF9, C11orf30, L3MBTL2, TBX5, EVI1, MAFK, BCL11A, USF1, REST, ARID1A, ATF7, ASH2L, ZNF605, HNRNPLL, TCF3, GLIS2, AATF, SMC3, NCOR2, STAG1, TRP47, CBFA2T2, FOXA2, TBL1X, EBF1, CHD2, BRF2, NFATC1, ZNF600, MTA3, MAFF, WT1, MEF2C, CDK9, HOXB13, BCL3, KDM1A, YY1, RELA, NEUROD1, AHR, ZNF148, BRG1, MCM3, SP140, TCF4, HIF1A, ZIC2, ZFP36, GATA3, ZNF519, BATF, TAL1, MAX, SPIB, ZNF143, GATA1, NRIP1, HAND2, PLAG1, TLE3, CEBPG, BCL11B, KLF4, CBX2, NR2F2, NEUROG2, NR2F1, KDM5B, TP53, ZBTB6, ZNF334, NFKB1, MYOD1, EGR2, ELF3, TBX21, BHLHE40, AR, TAF1, RXR, EGLN2, ZNF366, EGR1, HEXIM1, HSF1, NCOR1, BRD4, SCRT1, JUND, MAZ, TBX2, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): DNMT3L,PCBP3,LSS,SLC19A1,ADARB1,MCM3AP-AS1,COL6A2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 1275

Number of somatic mutations (non-coding): 215

Related genes and loops

Related gene: ENSG00000142182, ENSG00000197381, ENSG00000173638, ENSG00000183570, ENSG00000142173, ENSG00000160285, ENSG00000215424,

eachgene

Deatailed information for cohesin site CDBP00421388