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Basic information

CohesinDB ID: CDBP00421389

Locus: chr21-45905855-45907394

Data sourse: GSE206145-NatGen2015, GSE67783, ENCSR153HNT, GSE86191

Cell type: K-562, Fibroblast, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 51%, "14_ReprPCWk": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PATZ1, FOXA1, SUZ12, UBTF, ZFHX2, ATF3, CBFB, TP63, MYOG, ELF1, TEAD1, TRIM28, ESR1, CTCF, JUN, TFAP2C, MYCN, ZNF263, TOP2A, CTBP1, ZBTB17, ZBTB48, DUX4, ZSCAN5A, ERG2, SP4, HIC1, ERG, OGG1, ZBTB8A, MYC, GRHL3, APC, STAT3, PRDM14, DNMT3B, NR3C1, EZH2, EBF3, GABPB1, SPI1, RUNX1, ZFX, TET2, CBX8, ERG3, SMARCC1, RUNX2, GATA4, ARNT, CHD1, ZNF3, KLF9, SP1, BCL11A, REST, ZBTB7A, HNRNPLL, GLIS2, AATF, NCOR2, STAG1, TRP47, FOXA2, ZNF600, WT1, YY1, RELA, TARDBP, BRG1, MCM3, SP140, ZFP36, HIF1A, ZIC2, GATA3, MAX, NRIP1, ZNF143, CBX2, NCOA3, NR2F1, KDM5B, ZNF334, EGR2, ZNF445, AR, EGR1, HEXIM1, HSF1, NCOR1, BRD4, MAZ, AHR

Target gene symbol (double-evidenced CRMs): PCBP3,DNMT3L,LSS,MCM3AP-AS1,ADARB1,SLC19A1,COL6A2

Function elements

Human SNPs: Myopia_(age_of_diagnosis)

Number of somatic mutations (coding): 72

Number of somatic mutations (non-coding): 6

Related genes and loops

Related gene: ENSG00000142182, ENSG00000197381, ENSG00000173638, ENSG00000183570, ENSG00000142173, ENSG00000160285, ENSG00000215424,

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Deatailed information for cohesin site CDBP00421389