- Basic information
- CohesinDB ID: CDBP00421390
- Locus: chr21-45908410-45911399
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Data sourse: GSE206145-GSE177045, GSE67783, GSE72082, GSE86191, GSE76893, ENCSR000EHW, GSE206145-NatGen2015, GSE206145, ENCSR153HNT, ENCSR000EHX, GSE68388, ENCSR703TNG
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Cell type: MCF-7, RPE, Fibroblast, HCT-116, SK-N-SH, K-562, HSPC, HuCC-T1
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 5% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
83% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 38%,
"5_TxWk": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: MBD3, FOXO1, NFIA, FOSL1, PGR, SMARCA2, NME2, PATZ1, FOXA1, SUZ12, PBX2, UBTF, ZNF28, ZFHX2, ATF3, NFIC, ZFP64, PRDM1, IKZF3, CBFB, ZNF273, MECOM, SMARCE1, TP63, MITF, TEAD1, ELF1, TRIM28, ETV1, KLF6, NFE2L2, ZNF217, ESR1, OCA2, LMO2, HDAC8, CTCF, TCF12, JUN, EP300, E4F1, PSIP1, ZBTB20, MNT, KLF1, DPF2, TRIM24, ZNF423, E2F1, NR5A2, GTF2F1, RBPJ, TFAP2C, GLIS1, JARID2, CHD8, BRD1, ZSCAN5D, MYCN, ZNF263, CDK7, POU5F1, CTBP1, ZBTB48, ZSCAN5A, STAT1, SRF, ZNF563, ERG2, HIC1, ZNF300, ERG, PBX1, OGG1, ZBTB8A, MYC, SMARCA4, RFX1, FOXP2, RAD21, GRHL3, STAT3, NKX3-1, PRDM14, IKZF1, RCOR1, DNMT3B, NFE2, ZNF667, NR3C1, CEBPB, ESRRA, KMT2A, CREB1, EZH2, BMPR1A, GRHL2, EBF3, ZHX2, SPI1, KLF17, PCBP1, HDAC2, GATA2, GATAD2B, FLI1, HCFC1R1, MRTFB, NCOA2, ZNF554, ATF1, RUNX1, CBX1, SMC1A, MAFG, SIRT6, BCL6, CEBPA, SIN3A, ZFX, TET2, ERG3, CBX8, TWIST1, PRDM10, SMARCC1, ZXDC, CREBBP, NOTCH1, RUNX2, GR, NFIB, ARNT, NRF1, ZBTB10, CHD1, FOS, MED1, ZEB1, KDM6B, ZNF680, SCRT2, ZNF3, NR1H2, KLF9, L3MBTL2, EVI1, USF1, NIPBL, TFAP2A, MAFK, BCL11A, REST, HNRNPLL, CTBP2, MBD2, GLIS2, TCF3, AATF, STAG1, TRP47, CBFA2T2, FOXA2, MTA3, EBF1, CHD2, SS18, HDAC6, ZNF600, ZSCAN16, ZNF692, WT1, YY1, RELA, BRG1, SP140, ZIC2, HIF1A, ZFP36, OTX2, GATA3, MAF1, MAX, NRIP1, ZNF143, GATA1, PLAG1, CBX2, KLF4, CEBPG, NCOA3, NR2F2, ZNF544, NR2F1, TCF7L2, KDM5B, TP53, ZBTB6, ZNF334, MYOD1, EGR2, BRD2, ELF3, AR, ZNF445, ZNF579, RXR, ZBTB42, HEXIM1, EGR1, HSF1, BRD4, SCRT1, JUND, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): LSS,ADARB1,PCBP3,DNMT3L,COL6A2,MCM3AP-AS1,SLC19A1
- Function elements
- Human SNPs: Macular_thickness
- Number of somatic mutations (coding): 480
- Number of somatic mutations (non-coding): 75
- Related genes and loops
- Related gene:
ENSG00000142182,
ENSG00000197381,
ENSG00000173638,
ENSG00000183570,
ENSG00000142173,
ENSG00000160285,
ENSG00000215424,
- Related loop:
chr21:44250000-44275000~~chr21:45900000-45925000,
chr21:45125000-45150000~~chr21:45900000-45925000,
chr21:45200000-45225000~~chr21:45900000-45925000,
chr21:45325000-45350000~~chr21:45900000-45925000,
chr21:45550000-45575000~~chr21:45900000-45925000,
chr21:45575000-45600000~~chr21:45900000-45925000,
chr21:45675000-45700000~~chr21:45900000-45925000,
chr21:45700000-45725000~~chr21:45900000-45925000,
chr21:45725000-45750000~~chr21:45900000-45925000,
chr21:45750000-45775000~~chr21:45900000-45925000,
chr21:45900000-45925000~~chr21:46100000-46125000,
chr21:45900000-45925000~~chr21:46200000-46225000,