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Basic information

CohesinDB ID: CDBP00421394

Locus: chr21-45918949-45920374

Data sourse: ENCSR000BLD, ENCSR000BTU, GSE67783, GSE86191, GSE111913, GSE105028, GSE206145-NatGen2015, ENCSR000ECE, ENCSR153HNT, GSE145327, GSE97394

Cell type: H1-hESC, Fibroblast, HCT-116, Ishikawa, HUES64, RT-112, K-562, HSPC, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 3% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.900

Subunit: SA1,Rad21,SA2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 51%, "14_ReprPCWk": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: RUNX1, NFATC3, TRP47, CHD8, BRD1, FOXA2, MYCN, PPARG, TOP2A, NFATC1, ZFX, NME2, ZBTB48, WT1, DUX4, FOXA1, TET2, ERG, YY1, RELA, PBX1, OGG1, ATF3, MYC, RAD21, SP140, GRHL3, HIF1A, ARNT, SOX11, CBFB, PRDM9, STAT3, SPIB, CHD1, TERF2, PLAG1, NR3C1, KMT2A, MYB, EZH2, ESR1, ZIM3, TP53, ZNF334, CTCF, SPI1, AR, RXR, FLI1, HSF1, BRD4, TCF3, MAZ, AATF, SMC3, STAG1

Target gene symbol (double-evidenced CRMs): LSS,MCM3AP-AS1,PCBP3,COL6A2,ADARB1,DNMT3L,SLC19A1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 42

Number of somatic mutations (non-coding): 4

Related genes and loops

Related gene: ENSG00000142182, ENSG00000197381, ENSG00000173638, ENSG00000183570, ENSG00000142173, ENSG00000160285, ENSG00000215424,

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Deatailed information for cohesin site CDBP00421394