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Basic information

CohesinDB ID: CDBP00421395

Locus: chr21-45921404-45925225

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM2610, SLK, CVB-hiPSC, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, HEKn, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, Monocytes, GM18505, MB157, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, MCF-7, GM12892, T-47D, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, HeLa, BGO3, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 62% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.278

Subunit: SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TES,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 42%, "14_ReprPCWk": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, FOSL1, TRIM25, PGR, XBP1, FOXA1, RXRB, KDM3A, ATF3, THAP1, CTCFL, ZNF444, CBFB, MORC2, ZNF189, TP63, ZNF320, KLF5, ELF1, TEAD1, TRIM28, ESR1, USF2, CTCF, TCF12, DPF2, E2F6, PRKDC, E2F1, ZNF528, SMC1, TEAD4, FOXA3, GTF2F1, GATAD2A, RBPJ, TFAP2C, EED, NANOG, CHD8, BRD1, MYCN, ZNF263, POU5F1, ZNF778, TOP2A, ZBTB48, STAT1, SRF, GATAD1, ERG, ASCL1, MYC, EZH1, ZNF2, KDM4A, RAD21, FOXP2, GRHL3, GABPA, APC, XRCC5, NKX3-1, RCOR1, MIER3, NR2F6, VDR, NR3C1, SRSF3, CREB1, EZH2, JMJD6, FEZF1, GABPB1, SPI1, GATA2, MXD3, MXI1, ZGPAT, SMARCA5, HCFC1R1, MRTFB, PTBP1, ETV5, SMC1A, ZBTB24, CBX1, BCL6, ZFX, SMAD3, TET2, ZNF654, TRIM22, CREBBP, ZBTB2, NOTCH1, ZNF35, ZNF384, RUNX2, ARNT, ZNF48, ATF2, SMAD4, PRDM9, FOS, CDK8, HMGXB4, MED1, TEAD3, ZNF680, PIAS1, SMAD1, KLF9, L3MBTL2, SETDB1, BCL11A, IKZF5, REST, ATF7, ASH2L, TCF3, SMC3, STAG1, STAG2, AGO1, TBL1X, FOXA2, CHD2, MIER2, WT1, MEF2C, CDK9, ZNF580, MPHOSPH8, KDM1A, YY1, RELA, NEUROD1, BRG1, SP140, TCF4, HIF1A, GATA3, MAX, ZNF143, PLAG1, TCF7L2, NR2F1, KDM5B, ZNF687, TP53, ZSCAN22, MYOD1, ELF3, BRD2, BHLHE40, AR, ZNF324, EGLN2, ZBTB42, HEXIM1, RB1, HSF1, ZBTB26, BRD4, JUND, CLOCK, CUX1, MAZ, AHR

Target gene symbol (double-evidenced CRMs): SLC19A1,COL18A1,DNMT3L,ADARB1,LSS,COL6A2,PCBP3,MCM3AP-AS1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 456

Number of somatic mutations (non-coding): 45

Related genes and loops

Related gene: ENSG00000142182, ENSG00000197381, ENSG00000182871, ENSG00000173638, ENSG00000183570, ENSG00000142173, ENSG00000160285, ENSG00000215424,

eachgene

Deatailed information for cohesin site CDBP00421395