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Basic information

CohesinDB ID: CDBP00421398

Locus: chr21-45927607-45933291

Data sourse: GSE67783, GSE86191, GSE98367, GSE206145-NatGen2015, GSE120943, ENCSR153HNT, GSE131606

Cell type: Fibroblast, HCT-116, Monocytes, K-562, HSPC, Macrophage, DKO

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 2% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.922

Subunit: SA1,Rad21,SA2,SMC1

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 83% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 39%, "14_ReprPCWk": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOSL1, PGR, E2F7, XBP1, SUZ12, ZFHX2, HNRNPK, ATF3, PRDM1, CBFB, TP63, MITF, ZNF320, TEAD1, TRIM28, ESR1, OCA2, CTCF, JUN, TCF12, MNT, IRF4, E2F4, SMC1, ZNF175, TFAP2C, GLIS1, POU2F2, BRD1, ZNF263, MYCN, POU5F1, ZBTB48, ZSCAN5A, STAT1, ERG2, SP4, ERG, OGG1, MYC, RFX1, RAD21, GRHL3, BATF3, GABPA, STAT3, DNMT3B, NR3C1, CREB1, EZH2, BMPR1A, KLF17, PCBP1, GATA2, MXD3, FLI1, ZNF490, MRTFB, RUNX1, ZFX, PCBP2, TET2, ERG3, ZBTB2, RARA, GR, ARNT, ATF2, CHD1, CDK8, FOS, KDM6B, ZNF331, EVI1, TBX5, STAT5A, SP1, REST, ZBTB7A, PHIP, GLIS2, TCF3, AATF, SMC3, STAG1, TRP47, FOXA2, AGO1, WT1, CDK9, HOXB13, KDM1A, YY1, RELA, JUNB, AHR, SP140, ZFP36, HIF1A, BATF, MAX, ZNF143, PLAG1, NCOA3, NR2F1, KDM5B, TP53, ZNF334, MYOD1, EGR2, BHLHE40, AR, RXR, HEXIM1, EGR1, TFIIIC, ZBTB26, HSF1, BRD4, MAZ, ZNF316

Target gene symbol (double-evidenced CRMs): COL18A1,PCBP3,SLC19A1,ADARB1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 816

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000197381, ENSG00000182871, ENSG00000173638, ENSG00000183570,

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Deatailed information for cohesin site CDBP00421398