Deatailed information for cohesin site CDBP00421401

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  • Basic information
  • CohesinDB ID: CDBP00421401
  • Locus: chr21-45937087-45942541
  • Data sourse: GSE206145-GSE177045, GSE67783, GSE86191, GSE111913, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE165895
  • Cell type: MCF-7, RPE, Fibroblast, HCT-116, RT-112, K-562, HSPC, HFFc6
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 3% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.911
  • Subunit: Mau2,SA1,Rad21,SMC1
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TES,Intragenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 83% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 37%, "9_Het": 20%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: MBD3, FOXO1, FOSL1, PGR, ZSCAN5C, MEIS2, XBP1, PATZ1, FOXA1, SUZ12, RBFOX2, PBX2, UBTF, ZNF28, ZFHX2, TFAP4, ZNF90, ATF3, NFIC, BMI1, ZFP64, THAP1, CTCFL, IKZF3, ZNF444, ZNF429, ATF4, CBFB, ZNF189, TP63, ZNF320, ZNF467, JMJD1C, MAF, KLF5, ZNF586, TRIM28, ELF1, TEAD1, SNAI2, ZNF506, ZNF629, LMO2, ESR1, OCA2, ETV1, NFE2L2, HDAC8, USF2, ZFP91, CTCF, TCF12, JUN, EP300, KLF1, PSIP1, MNT, LMO1, GATA6, E4F1, DPF2, PAX8, BAF155, E2F6, TRIM24, SOX6, E2F4, E2F1, ZNF528, ZNF350, ZNF280A, TEAD4, TFAP2C, RBPJ, GLIS1, POU2F2, BRD1, ZSCAN5D, MYCN, ZNF263, TOP2A, ID3, CDK7, CTBP1, ZSCAN21, ZBTB17, ZBTB48, ZSCAN5A, STAT1, ZNF205, SRF, DDX5, NBN, ERG2, SP4, TBP, ERG, PBX1, ASCL1, OGG1, ZNF341, MYC, MYOG, SMARCA4, RAD21, GRHL3, PROX1, GABPA, STAT3, XRCC5, APC, PRDM14, IKZF1, RCOR1, HNRNPH1, DNMT3B, VDR, NR3C1, CEBPB, SRSF3, ZNF750, KMT2A, CREB1, EZH2, GRHL2, GABPB1, ZHX2, SPI1, KLF17, IRF1, PCBP1, HDAC2, GATA2, ZNF257, SREBF1, FLI1, HCFC1, ZNF490, HCFC1R1, MRTFB, ZNF76, NCOA2, ZIM3, MYF5, ATF1, ETV5, PTBP1, RUNX1, BCL6, SMC1A, HDAC1, EZH2phosphoT487, SIRT6, CBX1, SIN3A, ZFX, TET2, ERG3, NFXL1, ZNF770, CBX8, ZNF549, SMARCC1, PRDM10, ZNF18, ZBTB2, ZNF35, NOTCH1, CREBBP, TAF15, RUNX2, CDK6, GATA4, OSR2, GR, ZNF184, SP3, ARNT, NFIB, TFDP1, NRF1, ZNF48, PRDM9, ZEB2, FOXM1, NCAPH2, SP2, FOS, CHD1, CDK8, MED1, ZEB1, TEAD3, KDM6B, MYB, SCRT2, ZNF680, PIAS1, VEZF1, ZNF3, KLF9, C11orf30, L3MBTL2, SETDB1, SREBF2, EVI1, TBX5, USF1, MAFK, BCL11A, SP1, TFAP2A, ARID2, REST, ZNF479, ZBTB7A, ATF7, ASH2L, HNRNPLL, PHIP, TCF3, GLIS2, THRA, MBD2, AATF, STAG1, NFATC3, TRP47, CBFA2T2, KLF13, AGO1, FOXA2, EBF1, CBX3, SS18, MTA3, ZNF600, ZNF692, CREM, WT1, CDK9, YY2, HOXB13, ZKSCAN1, KDM1A, YY1, RELA, CREB3L1, TARDBP, NEUROD1, AHR, ZNF148, BRG1, MCM3, SP140, TCF4, HIF1A, ZIC2, ZFP36, OTX2, ZNF311, GATA3, KLF15, MGA, TAL1, MAX, NRIP1, ZNF143, GATA1, ZNF449, PLAG1, KLF4, BCL11B, SP7, ZNF281, GFI1B, ZNF141, NEUROG2, NR2F1, KDM5B, TCF7L2, TP53, PKNOX1, ZBTB6, ZNF547, ZNF334, BCL6B, MYOD1, EGR2, ZSCAN22, T, BRD2, ARRB1, ZFP28, AR, ZNF445, ZBTB40, RXR, ZNF324, EGLN2, ZNF366, EGR1, ZNF280D, HEXIM1, HSF1, RNF2, ZBTB42, SCRT1, BRD4, JUND, CLOCK, MAZ, ZNF316
  • Target gene symbol (double-evidenced CRMs): COL18A1,PCBP3,ADARB1,SLC19A1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 954
  • Number of somatic mutations (non-coding): 80
  • Related genes and loops
  • Related gene: ENSG00000197381, ENSG00000182871, ENSG00000173638, ENSG00000183570,
  • Related loop: chr21:45025000-45050000~~chr21:45925000-45950000, chr21:45200000-45225000~~chr21:45925000-45950000, chr21:45325000-45350000~~chr21:45925000-45950000, chr21:45450000-45475000~~chr21:45925000-45950000, chr21:45550000-45575000~~chr21:45925000-45950000, chr21:45575000-45600000~~chr21:45925000-45950000, chr21:45725000-45750000~~chr21:45925000-45950000,
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