- Basic information
- CohesinDB ID: CDBP00421405
- Locus: chr21-45953686-45954738
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Data sourse: ENCSR000BLD, ENCSR000BTQ, GSE67783, ENCSR000BKV, GSE72082, GSE86191, ENCSR000HPG, ENCSR000BLY, ENCSR000EHW, GSE105028, ENCSR000ECE, ShirahigeLab-NatGen2015, ENCSR000EHX, ENCSR153HNT, GSE83726, GSE116344, GSE25021, GSE97394
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Cell type: MCF-7, H1-hESC, Fibroblast, HCT-116, RH4, HUES64, IMR-90, SK-N-SH, K-562, HSPC, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 9% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.878
- Subunit: SA1,Rad21,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
83% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"14_ReprPCWk": 35%,
"15_Quies": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: BRD1, TOP2A, ZFX, ZNF600, ZSCAN5A, SRF, SUZ12, TWIST1, TBP, SMARCC1, NEUROD1, NFIC, BRG1, RAD21, SOX11, OTX2, HMBOX1, APC, TP63, ZNF143, HAND2, MED1, PLAG1, ELF1, TP53, PKNOX1, ESR1, TBX5, CTCF, BRD2, TCF12, GATA6, POU2F3, MAZ, SMC3, STAG1
- Target gene symbol (double-evidenced CRMs): COL6A2,MCM3AP-AS1,LSS,FTCD
- Function elements
- Human SNPs: Bone_mineral_density_(lumbar_spine)_in_inflammatory_bowel_disease
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 1
- Related genes and loops
- Related gene:
ENSG00000142173,
ENSG00000160282,
ENSG00000160285,
ENSG00000215424,
- Related loop:
chr21:45025000-45050000~~chr21:45925000-45950000,
chr21:45200000-45225000~~chr21:45925000-45950000,
chr21:45325000-45350000~~chr21:45925000-45950000,
chr21:45450000-45475000~~chr21:45925000-45950000,
chr21:45550000-45575000~~chr21:45925000-45950000,
chr21:45575000-45600000~~chr21:45925000-45950000,
chr21:45725000-45750000~~chr21:45925000-45950000,
chr21:45950000-45975000~~chr21:46050000-46075000,
chr21:45950000-45975000~~chr21:46075000-46100000,
chr21:45950000-45975000~~chr21:46100000-46125000,
chr21:45950000-45975000~~chr21:46125000-46150000,
chr21:45950000-45975000~~chr21:46200000-46225000,