- Basic information
- CohesinDB ID: CDBP00421411
- Locus: chr21-45966146-45976202
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Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE36578, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
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Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, HSPC, CVI-hiPSC, Liver, GP5d, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, TC-71, GM12891, GM2588, GBM39, HUES9, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, CNCC-WT33iPSC, BGO3, OCI-AML-3, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 78% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.167
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: TSS,TES,Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
83% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"7_Enh": 15%,
"12_EnhBiv": 14%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: ZNF384, ZNF644, CEBPA, TOP2A, ARNT, DUX4, SP1, AHR, HNF4A
- Target gene symbol (double-evidenced CRMs): COL6A2,FTCD,MCM3AP-AS1,LSS
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 61
- Related genes and loops
- Related gene:
ENSG00000142173,
ENSG00000160282,
ENSG00000160285,
ENSG00000215424,
- Related loop:
chr21:45950000-45975000~~chr21:46050000-46075000,
chr21:45950000-45975000~~chr21:46075000-46100000,
chr21:45950000-45975000~~chr21:46100000-46125000,
chr21:45950000-45975000~~chr21:46125000-46150000,
chr21:45950000-45975000~~chr21:46200000-46225000,
chr21:45969912-45971939~~chr21:46146852-46148242,
chr21:45969927-45971657~~chr21:46143028-46144654,
chr21:45969938-45971632~~chr21:46097212-46099767,
chr21:45972574-45974684~~chr21:46096717-46099725,
chr21:45972821-45974610~~chr21:46143050-46144647,
chr21:45972840-45974615~~chr21:46096634-46099688,
chr21:45972865-45974723~~chr21:46097212-46099767,
chr21:45972883-45974607~~chr21:46096709-46099711,
chr21:45972910-45974653~~chr21:46097148-46100727,
chr21:45972910-45974653~~chr21:46143028-46144654,
chr21:45973206-45974743~~chr21:46096706-46098645,
chr21:45973208-45974665~~chr21:46096817-46098665,
chr21:45975000-46000000~~chr21:46075000-46100000,
chr21:45975000-46000000~~chr21:46100000-46125000,
chr21:45975000-46000000~~chr21:46125000-46150000,
chr21:45980579-45983656~~chr21:46091541-46093549,