Deatailed information for cohesin site CDBP00421422

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  • Basic information
  • CohesinDB ID: CDBP00421422
  • Locus: chr21-46046458-46047697
  • Data sourse: GSE67783, GSE110061, GSE111913, GSE206145-NatGen2015, ENCSR153HNT, GSE116344
  • Cell type: Fibroblast, RH4, HCT-116, RT-112, K-562, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 2% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.933
  • Subunit: SA1,Rad21,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS,Intergenic
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 84% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 71%, "14_ReprPCWk": 11%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, TRIM25, ZNF195, NME2, FOXA1, HLF, MLL4, THAP1, IKZF3, MORC2, PAX5, ZNF320, TEAD1, LMO2, OCA2, MED26, ARID5B, PAX8, ZNF528, JARID2, NANOG, POU5F1, BRD3, ZNF263, TOP2A, CTBP1, DUX4, STAT1, ERG, ZBTB8A, EZH1, SMARCA4, RCOR1, NR2F6, CEBPB, CREB1, GABPB1, ZHX2, KLF17, GATA2, MXD3, FLI1, MXI1, NR2C2, RELB, RUNX1, CEBPA, CRY1, TET2, ZNF473, SP5, SMARCC1, PRDM10, ZBTB10, ATF2, FOXM1, SMARCB1, EVI1, STAT5A, IKZF5, MBD2, ELL2, CBFA2T2, MEF2B, ZNF207, CBX3, SS18, WT1, JUNB, ZNF311, BATF, MAF1, PLAG1, KLF4, BCL11B, ZNF544, ZBTB6, BCL6B, EGR2, ELF3, RBM14, RXR, EGLN2, HSF1, NCOR1, ZBTB26, SCRT1, ZNF316, FOSL1, SMARCA2, ZNF660, ZNF621, XBP1, KDM4B, PBX2, ATF3, RUNX3, CBFB, TP63, ZSCAN4, MITF, JMJD1C, MAF, ELF1, ZNF573, ZIK1, CTCF, JUN, LMO1, DPF2, IRF4, PDX1, TFAP2C, MTA2, ZBTB17, ZBTB48, SRF, DDX5, CHD4, PBX1, KDM4A, FOXP2, RXRA, PRDM14, HNRNPH1, VDR, NR3C1, STAT5B, KMT2A, GRHL2, EBF3, SMARCA5, EZH2phosphoT487, ZNF770, NFIB, ARNT, DAXX, ZNF48, ZEB2, PBX3, NCAPH2, TEAD3, KLF9, TBX5, USF1, SP1, TFAP2A, BCL11A, ZNF479, ASH2L, ZNF548, GLIS2, SMC3, STAG1, ZNF394, TRP47, AGO1, MTA3, EBF1, ZKSCAN1, KDM1A, BRG1, ZIC2, GATA3, TAL1, NRIP1, ZNF143, ZNF141, TP53, ZNF334, ZSCAN22, NFKB1, BRD2, ARRB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, PGR, SOX2, PATZ1, CHD7, ZNF444, ZNF189, KLF6, NFE2L2, ESR1, TP73, SOX4, E2F6, TRIM24, RFX5, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ERG2, HOXC5, OGG1, ETS1, MYC, NKX2-1, GABPA, STAT3, IKZF1, DNMT3B, EZH2, MRTFA, PHF8, SPI1, PCBP1, HDAC2, GATAD2B, ZNF554, SALL2, SIN3A, ERG3, CREBBP, ZNF384, RARA, TAF15, HMGB2, SMAD4, CDK8, ZEB1, SUPT16H, MAFK, REST, ARID1A, HNRNPLL, BCOR, FOXP1, AATF, PPARG, TBL1X, ZNF662, FOXO3, RELA, TARDBP, MAX, NR2F1, NEUROG2, KDM5B, TCF7L2, PKNOX1, MYOD1, T, AR, ZNF445, PAX3-FOXO1, ZBTB16, HEXIM1, AHR, FOSL2, MBD3, E2F7, SUZ12, RBFOX2, ZFHX2, LYL1, INSM2, NFIC, ZNF362, PRDM1, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, MLL, USF2, TCF12, EP300, ZNF512B, E2F1, TEAD4, EED, CHD8, BRD1, MYCN, RUNX1T1, CDK7, ARID3A, ASCL1, ZNF341, RAD21, GRHL3, PROX1, XRCC5, ZNF639, ARNTL, FEZF1, ZNF664, EHF, IRF1, MRTFB, ZIM3, MYF5, SMC1A, SIRT6, ZFX, SMAD3, NOTCH1, RUNX2, SMAD2, OSR2, ZNF184, PBX4, NR2C1, CHD1, FOS, MED1, KDM6B, MYB, SCRT2, SETDB1, HIF2A, NIPBL, ZBTB7A, PHIP, TCF3, ZNF283, FOXA2, RBBP5, ZNF600, CDK9, HOXB13, YY1, ZNF148, SP140, HIF1A, GATA1, CEBPG, SP7, NCOA3, NR2F2, BHLHE40, ZBTB42, MAZ, BRCA1
  • Target gene symbol (double-evidenced CRMs): FTCD,COL6A2
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 13
  • Related genes and loops
  • Related gene: ENSG00000142173, ENSG00000160282,
  • Related loop: chr21:44850000-44875000~~chr21:46050000-46075000, chr21:45300000-45325000~~chr21:46050000-46075000, chr21:45325000-45350000~~chr21:46050000-46075000, chr21:45350000-45375000~~chr21:46050000-46075000, chr21:45625000-45650000~~chr21:46050000-46075000, chr21:45675000-45700000~~chr21:46050000-46075000, chr21:45725000-45750000~~chr21:46050000-46075000, chr21:45875000-45900000~~chr21:46050000-46075000, chr21:45950000-45975000~~chr21:46050000-46075000, chr21:46025000-46050000~~chr21:46125000-46150000,
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