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Basic information

CohesinDB ID: CDBP00421423

Locus: chr21-46048586-46063227

Data sourse: ENCSR000BLD, GSE104888, ENCSR230ZWH, GSE116868, ENCSR000BLY, GSE105028, GSE103477, GSE131606, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE165895, GSE67783, GSE86191, GSE206145-NatGen2015, GSE135093, ENCSR703TNG, GSE106870, GSE116344, GSE118494, GSE206145, GSE110061, GSE129526, ENCSR000HPG, GSE111913, ENCSR153HNT, GSE68388, GSE83726, GSE38411

Cell type: RH4, CVI-hiPSC, Liver, HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, IMR-90, K-562, BCBL-1, HFFc6, DKO, H1-hESC, MB157, SK-N-SH, RT-112, THP-1, MCF-7, HCT-116, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 14% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.767

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES,Intergenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 84% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "7_Enh": 28%, "15_Quies": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: AR, NR3C1, BCL6

Target gene symbol (double-evidenced CRMs): FTCD,PCBP3,PTTG1IP,COL6A2

Function elements

Human SNPs: Waist_circumference_adjusted_for_body_mass_index

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 163

Related genes and loops

Related gene: ENSG00000183255, ENSG00000183570, ENSG00000142173, ENSG00000160282,

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Deatailed information for cohesin site CDBP00421423