- Basic information
- CohesinDB ID: CDBP00421425
- Locus: chr21-46071064-46071598
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Data sourse: GSE67783, GSE86191, GSE206145, GSE206145-NatGen2015, ENCSR153HNT
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Cell type: RPE, Fibroblast, HCT-116, K-562, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.944
- Subunit: SA1,Rad21,SA2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
84% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 59%,
"14_ReprPCWk": 26%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, CBX5, ZNF195, ZNF621, NME2, FOXA1, SUZ12, PBX2, ZFHX2, HNRNPK, ZNF90, ATF3, NFIC, ZFP64, CTCFL, PRDM1, CBFB, MORC2, PAX5, TP63, ZSCAN4, MITF, ZNF320, KLF5, ELF1, TRIM28, TEAD1, ETV1, KLF6, LMO2, ESR1, OCA2, HDAC8, USF2, CTCF, TCF12, JUN, E4F1, KLF1, MNT, ZBTB20, DPF2, PAX8, E2F6, GLI4, E2F1, ZNF350, TEAD4, TFAP2C, EED, JARID2, NANOG, POU2F2, BRD1, ZSCAN5D, MYCN, ZNF263, RUNX1T1, CHD8, POU5F1, ZNF649, ZBTB17, ZBTB48, ZSCAN5A, STAT1, DDX5, ERG2, ERG, OGG1, ZNF341, ETS1, MYC, TRIP13, RFX1, RAD21, GRHL3, RXRA, GABPA, STAT3, XRCC5, PRDM14, IKZF1, NFE2, DNMT3B, RCOR1, ZNF398, NR3C1, CEBPB, KMT2A, CREB1, EZH2, BMPR1A, GRHL2, ZNF652, GABPB1, ZHX2, ELF4, SPI1, PCBP1, HDAC2, GATA2, SSRP1, MXD3, SIX2, ZNF146, FLI1, MXI1, NFYB, ZNF554, ATF1, ETV5, RUNX1, CBX1, CEBPA, LDB1, CRY1, AFF4, ZFX, POU4F2, TET2, ERG3, CBX8, ZNF473, ZNF549, ZNF384, NOTCH1, RUNX2, CDK6, ZNF184, ARNT, ZNF48, NFYA, CBFA2T3, PBX3, SP2, FOS, NCAPH2, ETV6, MED1, TEAD3, CEBPD, MYB, ZNF3, SETDB1, EVI1, USF1, SP1, BCL11A, NR4A1, REST, ZBTB7A, HNRNPLL, BCOR, TCF3, FOXP1, AATF, SMC3, STAG1, NFATC3, PAX7, TRP47, CBFA2T2, CBX3, AGO1, CREM, FOXA2, RBBP5, ZNF600, WT1, ZNF662, BCL3, KDM1A, YY1, RELA, ZNF148, SP140, ZIC2, HIF1A, ZNF311, TAL1, MAX, ZNF143, AGO2, GATA1, PLAG1, CBX2, KLF4, NEUROG2, NR2F1, KDM5B, TP53, ZNF334, EGR2, ELF3, BHLHE40, AR, ZBTB40, RXR, ZNF366, HEXIM1, HSF1, ZBTB26, RNF2, BRD4, MYNN, MAZ, ZNF24, AHR
- Target gene symbol (double-evidenced CRMs): PCBP3,PTTG1IP
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 7
- Related genes and loops
- Related gene:
ENSG00000183255,
ENSG00000183570,
- Related loop:
chr21:27500000-27525000~~chr21:46075000-46100000,
chr21:44850000-44875000~~chr21:46050000-46075000,
chr21:45300000-45325000~~chr21:46050000-46075000,
chr21:45325000-45350000~~chr21:46050000-46075000,
chr21:45350000-45375000~~chr21:46050000-46075000,
chr21:45625000-45650000~~chr21:46050000-46075000,
chr21:45675000-45700000~~chr21:46050000-46075000,
chr21:45725000-45750000~~chr21:46050000-46075000,
chr21:45875000-45900000~~chr21:46050000-46075000,
chr21:45950000-45975000~~chr21:46050000-46075000,
chr21:45950000-45975000~~chr21:46075000-46100000,
chr21:45975000-46000000~~chr21:46075000-46100000,