- Basic information
- CohesinDB ID: CDBP00421426
- Locus: chr21-46077624-46086016
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Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE116868, ENCSR000BLY, GSE105028, GSE131606, GSE165895, ENCSR000EFJ, GSE67783, GSE86191, GSE206145-NatGen2015, GSE112028, GSE116344, ENCSR338DUC, ENCSR000EHW, GSE206145, ENCSR000EHX, ENCSR167MTG, ENCSR000HPG, GSE111913, ENCSR153HNT, GSE68388
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Cell type: RH4, Liver, HuCC-T1, H9-hESC, RPE, Fibroblast, IMR-90, K-562, DKO, HFFc6, H1-hESC, MB157, SK-N-SH, RT-112, HeLa-Tet-On, MCF-7, HCT-116, Hep-G2, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 11% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.789
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
84% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 25%,
"7_Enh": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, TRIM25, E2F7, NME2, XBP1, FOXA1, HLF, SUZ12, ZNF28, ZFHX2, ZNF90, ATF3, ZBTB5, CHD7, ZNF444, CBFB, ZSCAN4, TP63, ZNF320, JMJD1C, ELF1, TRIM28, ZNF573, TEAD1, SNAI2, NFE2L2, KLF6, ESR1, OCA2, MED26, PITX3, HDAC8, USF2, CTCF, TCF12, JUN, EP300, BAF155, MNT, PAX8, E2F6, E2F4, ZNF410, E2F1, ZNF280A, TEAD4, KMT2B, ZNF92, GTF2F1, TFAP2C, GLIS1, JARID2, POU2F2, CHD8, BRD1, ZSCAN5D, MYCN, ZNF263, BRD3, POU5F1, TOP2A, NANOG, ZBTB17, ZBTB48, ZSCAN5A, DUX4, ZNF205, SRF, DDX5, ERG2, HOXC5, ERG, ASCL1, OGG1, EZH1, MYC, SMARCA4, RAD21, FOXP2, GRHL3, RXRA, GABPA, STAT3, XRCC5, NKX3-1, PRDM14, RCOR1, DNMT3B, ARNTL, NR3C1, ESRRA, SRSF3, KMT2A, CREB1, EZH2, GRHL2, EBF3, MRTFA, GABPB1, ZHX2, ZNF436, SPI1, HDAC2, GATA2, SSRP1, FLI1, MXI1, RELB, MRTFB, NFIL3, ETV5, PTBP1, RUNX1, HDAC1, SIRT6, CRY1, SIN3A, ZFX, POU4F2, SMAD3, TET2, ERG3, SMARCC1, TWIST1, ZBTB2, CREBBP, NOTCH1, TAF15, RUNX2, GR, ZNF184, ARNT, DAXX, NFIB, SOX11, ZNF48, PBX3, NCAPH2, FOS, CHD1, MED1, GMEB1, TEAD3, KDM6B, SCRT2, ZMYM3, PIAS1, SUPT16H, ZNF3, KLF9, SETDB1, USF1, SP1, BCL11A, ARID2, REST, ZBTB7A, HNRNPLL, BCOR, TCF3, GLIS2, AATF, SMC3, STAG1, MLLT1, NFATC3, ZNF394, TRP47, ZNF316, AGO1, FOXA2, EBF1, CHD2, SS18, NFATC1, ZNF600, BRF2, GTF2B, WT1, RBBP5, ESR2, ZNF662, ZBTB33, BCL3, KDM1A, ZNF19, RELA, YY1, TARDBP, BRG1, MCM3, SP140, ZIC2, HIF1A, TCF4, ZFP36, MAX, ZNF143, AGO2, HAND2, PLAG1, ZNF223, NR2F1, NEUROG2, KDM5B, TP53, PKNOX1, ZNF334, ZSCAN22, MYOD1, EGR2, PHOX2B, BHLHE40, AR, PAX3-FOXO1, TAF1, EGLN2, EGR1, HEXIM1, TFIIIC, HSF1, ZBTB26, BRD4, JUND, SCRT1, CLOCK, MAZ, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): COL6A1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 85
- Related genes and loops
- Related gene:
ENSG00000142156,
- Related loop:
chr21:27500000-27525000~~chr21:46075000-46100000,
chr21:44850000-44875000~~chr21:46050000-46075000,
chr21:45300000-45325000~~chr21:46050000-46075000,
chr21:45325000-45350000~~chr21:46050000-46075000,
chr21:45350000-45375000~~chr21:46050000-46075000,
chr21:45625000-45650000~~chr21:46050000-46075000,
chr21:45675000-45700000~~chr21:46050000-46075000,
chr21:45725000-45750000~~chr21:46050000-46075000,
chr21:45875000-45900000~~chr21:46050000-46075000,
chr21:45950000-45975000~~chr21:46050000-46075000,
chr21:45950000-45975000~~chr21:46075000-46100000,
chr21:45975000-46000000~~chr21:46075000-46100000,