- Basic information
- CohesinDB ID: CDBP00421428
- Locus: chr21-46090704-46094379
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Data sourse: ENCSR230ZWH, GSE72082, GSE25021, GSE165895, ENCSR000EFJ, ENCSR917QNE, GSE67783, ENCSR000BKV, GSE86191, GSE206145-NatGen2015, GSE135093, GSE120943, GSE116344, GSE118494, GSE98367, ENCSR000BLS, GSE206145, ENCSR000HPG, ENCSR153HNT, GSE68388, GSE83726
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Cell type: MCF-7, Macrophage, RPE, Fibroblast, HCT-116, Monocytes, Hep-G2, RH4, IMR-90, K-562, Liver, HSPC, HuCC-T1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 10% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.844
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
84% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 21%,
"7_Enh": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: AR, CEBPB, HOXB13, TRIM28, ZNF264, POU5F1, ZNF331, ZFX, EZH2, GRHL3, ESR1, NCOR1, CREB1, ZNF616, FOXA1, ZNF334, ZNF311, CTCF, ZNF143, TFAP2C
- Target gene symbol (double-evidenced CRMs): COL6A2,COL6A1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 43
- Related genes and loops
- Related gene:
ENSG00000142156,
ENSG00000142173,
- Related loop:
chr21:27500000-27525000~~chr21:46075000-46100000,
chr21:45950000-45975000~~chr21:46075000-46100000,
chr21:45969938-45971632~~chr21:46097212-46099767,
chr21:45972574-45974684~~chr21:46096717-46099725,
chr21:45972840-45974615~~chr21:46096634-46099688,
chr21:45972865-45974723~~chr21:46097212-46099767,
chr21:45972883-45974607~~chr21:46096709-46099711,
chr21:45972910-45974653~~chr21:46097148-46100727,
chr21:45973206-45974743~~chr21:46096706-46098645,
chr21:45973208-45974665~~chr21:46096817-46098665,
chr21:45975000-46000000~~chr21:46075000-46100000,
chr21:45980579-45983656~~chr21:46091541-46093549,
chr21:45981275-45983496~~chr21:46096634-46099688,
chr21:45981311-45983330~~chr21:46091781-46093342,