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Basic information

CohesinDB ID: CDBP00421429

Locus: chr21-46094789-46101183

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE116868, ENCSR760NPX, GSE126634, ENCSR000BLY, ENCSR150EFU, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, ENCSR330ELC, GSE25021, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, GSE143937, GSE165895, GSE67783, ENCSR000BKV, GSE115250, GSE86191, GSE76893, GSE206145-NatGen2015, ENCSR806UKK, GSE135093, GSE112028, GSE130135, ENCSR199XBQ, ENCSR703TNG, GSE106870, GSE116344, GSE138105, GSE145327, ENCSR895JMI, GSE118494, GSE76815, GSE115248, ENCSR193NSH, ENCSR768DOX, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR247LSH, ENCSR807WAC, ENCSR000EHX, ENCSR620NWG, ENCSR767DFK, ENCSR981FDC, ENCSR495WGO, ENCSR984DZW, GSE97394, ENCSR217ELF, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE131956, GSE110061, GSE129526, ENCSR000HPG, ENCSR676MJK, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR537EFT, ENCSR153HNT, GSE68388, GSE83726, GSE50893, ENCSR748MVX

Cell type: MDM, RH4, SLK, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, Kelly, IMR-90, K-562, HFFc6, DKO, H1-hESC, GM18505, MB157, GM12878, GM12891, GBM39, SK-N-SH, RT-112, HeLa-Tet-On, HAP1, THP-1, HUES64, MCF-7, HCT-116, HEK293T, Hep-G2, A-549, OCI-AML-3, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 42% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.589

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 84% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "14_ReprPCWk": 17%, "13_ReprPC": 14%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, TRIM25, NME2, FOXA1, IKZF3, ZNF429, MORC2, TEAD1, ZNF121, OCA2, MED26, HDAC8, ZNF561, ZNF577, ZNF157, ZNF211, E2F4, ZNF410, ZNF528, KMT2B, JARID2, NANOG, POU5F1, BRD3, ZNF263, TOP2A, CTBP1, STAT1, ZNF485, SAP130, ERG, SMARCA4, FOXK2, ZNF398, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, KLF17, ZNF257, GATA2, MXD3, FLI1, MXI1, HCFC1R1, RUNX1, HDAC1, ZNF707, CRY1, TET2, SP5, SMARCC1, ZBTB10, SP2, ARID2, NFATC3, CBFA2T2, ZNF207, CHD2, BRF2, SS18, PAF1, WT1, MCM3, ZFP36, MAF1, PLAG1, KLF4, RXR, HSF1, ZBTB26, SCRT1, ZNF483, FOSL1, XBP1, PBX2, HNRNPK, ATF3, ZFP64, CBFB, TP63, ZSCAN4, MITF, CDC5L, ZNF467, MAF, ELF1, SNAI2, CTCF, JUN, TAF3, LMO1, ZBTB20, DPF2, RYBP, TFAP2C, RBPJ, ZSCAN21, ZNF317, ZBTB48, SRF, DDX5, KDM4A, FOXP2, RXRA, LEF1, NR3C1, KMT2A, KLF8, GRHL2, ZBTB14, SSRP1, ZNF146, EZH2phosphoT487, ZNF18, SP3, ARNT, DAXX, ZNF48, PRDM9, PBX3, NCAPH2, TEAD3, KLF9, USF1, SP1, BCL11A, TFAP2A, ZNF479, ASH2L, CTBP2, GLIS2, SMC3, STAG1, STAG2, TRP47, SAFB, AGO1, MTA3, ZNF580, KLF7, ZKSCAN1, KDM1A, ZNF441, ZNF266, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, CBX2, TP53, ZNF645, NFKB1, BRD2, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, SPIN1, ZSCAN23, TBX2, ZNF468, PGR, PATZ1, UBTF, BMI1, CHD7, ATF4, KLF6, NFE2L2, SAP30, ESR1, TP73, KLF1, SOX4, E2F6, TRIM24, GTF2F1, GLIS1, ZBTB1, ZSCAN5A, ERG2, SP4, HNF4G, HOXC5, OGG1, ETS1, MYC, NKX2-1, GABPA, STAT3, IKZF1, ZNF343, SRSF3, EZH2, PHF8, SPI1, ZNF786, ZNF202, PCBP1, HDAC2, ZNF182, ZNF490, NCOA2, ZNF76, ZNF554, ETV5, BCL6, SIN3A, ERG3, CREBBP, ZNF384, TAF15, HMGB2, SMAD4, CDK8, SUPT16H, ZNF22, MAFK, HNF4A, REST, ARID1A, HNRNPLL, BCOR, FOXP1, AATF, CXXC4, PPARG, GTF2B, ZNF30, RELA, TARDBP, MAX, NEUROG2, NR2F1, KDM5B, ZNF547, MYOD1, AR, ZNF445, HEXIM1, AHR, FOSL2, MBD3, E2F7, HMGN3, MEIS2, SUZ12, RBFOX2, ZNF28, ZFHX2, INSM2, NFIC, ZNF362, CTCFL, ZBTB5, PRDM1, ZNF736, KLF5, TRIM28, ETV1, USF2, TCF12, BAF155, GLI4, RAD51, E2F1, SMC1, TEAD4, ZNF175, EED, CHD8, BRD1, MYCN, ID3, AEBP2, MCM5, RAD21, GRHL3, PROX1, XRCC5, NFE2, ZNF639, ARNTL, ZGPAT, MRTFB, ZIM3, PTBP1, MAFG, SMC1A, SIRT6, ZNF534, ZFX, SMAD3, NOTCH1, RUNX2, ZSCAN30, OSR2, NRF1, PBX4, CHD1, FOS, MED1, KDM6B, MYB, SCRT2, ZNF558, VEZF1, ZNF3, L3MBTL2, SETDB1, NIPBL, ZBTB7A, POU2F3, PHIP, TCF3, FOXA2, RBBP5, ZNF600, ZNF493, FOXF1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ASXL1, SP140, HIF1A, ZNF519, GATA1, CEBPG, SP7, NR2F2, ZNF837, BHLHE40, TAF1, ZBTB40, MYNN, CLOCK, MAZ

Target gene symbol (double-evidenced CRMs): PCBP3,COL6A1,FAM207A,COL18A1,COL6A2,ADARB1,LSS,MCM3AP-AS1,SLC19A1

Function elements

Human SNPs: Central_corneal_thickness

Number of somatic mutations (coding): 34

Number of somatic mutations (non-coding): 28

Related genes and loops

Related gene: ENSG00000160256, ENSG00000197381, ENSG00000182871, ENSG00000173638, ENSG00000183570, ENSG00000142156, ENSG00000142173, ENSG00000160285, ENSG00000215424,

eachgene

Deatailed information for cohesin site CDBP00421429