- Basic information
- CohesinDB ID: CDBP00421431
- Locus: chr21-46107500-46107764
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Data sourse: GSE206145-NatGen2015, GSE97394
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Cell type: Fibroblast, HUES64
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 0% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.978
- Subunit: Mau2,Rad21
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
84% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 32%,
"9_Het": 23%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, SOX2, XBP1, FOXA1, ZNF28, SFMBT1, ATF3, CHD7, PRDM1, TP63, TEAD1, TRIM28, ESR1, OCA2, USF2, CTCF, E2F1, TFAP2C, GLIS1, NANOG, CHD8, ZNF263, POU5F1, TOP2A, MYCN, ZBTB48, ZNF300, ERG, OGG1, MYC, EZH1, RAD21, GRHL3, KLF12, GABPA, APC, STAT3, XRCC5, DNMT3B, NR3C1, HNRNPL, EZH2, SPI1, SSRP1, HCFC1R1, RUNX1, SMC1A, NKX2-2, ZFX, SMAD3, TET2, ERG3, TWIST1, CREBBP, ZNF384, NOTCH1, ZBTB2, IRF2, RUNX2, ARNT, ZBTB10, ZNF48, ZEB2, SP2, CHD1, FOS, MED1, KDM6B, ZNF680, PIAS1, SUPT16H, NCOA1, SETDB1, USF1, NR4A1, RBM25, HNRNPLL, MBD2, AATF, SMC3, STAG1, TRP47, CBFA2T2, AGO1, FOXA2, CBX3, ZNF600, WT1, ZBTB33, CDK9, MPHOSPH8, KDM1A, YY1, RELA, TARDBP, AHR, SP140, ZIC2, HIF1A, TCF4, TAL1, ZNF143, PLAG1, GFI1B, NCOA3, NR2F1, KDM5B, TP53, AR, YAP1, EGLN2, HEXIM1, HSF1, BRD4, MAZ, ZNF316
- Target gene symbol (double-evidenced CRMs): LSS,COL6A1,COL6A2,MCM3AP-AS1,ADARB1,SLC19A1,FAM207A,PCBP3,COL18A1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000160256,
ENSG00000197381,
ENSG00000182871,
ENSG00000173638,
ENSG00000183570,
ENSG00000142156,
ENSG00000142173,
ENSG00000160285,
ENSG00000215424,
- Related loop:
chr21:44975000-45000000~~chr21:46100000-46125000,
chr21:45125000-45150000~~chr21:46100000-46125000,
chr21:45200000-45225000~~chr21:46100000-46125000,
chr21:45325000-45350000~~chr21:46100000-46125000,
chr21:45500000-45525000~~chr21:46100000-46125000,
chr21:45550000-45575000~~chr21:46100000-46125000,
chr21:45575000-45600000~~chr21:46100000-46125000,
chr21:45600000-45625000~~chr21:46100000-46125000,
chr21:45625000-45650000~~chr21:46100000-46125000,
chr21:45675000-45700000~~chr21:46100000-46125000,
chr21:45725000-45750000~~chr21:46100000-46125000,
chr21:45750000-45775000~~chr21:46100000-46125000,
chr21:45900000-45925000~~chr21:46100000-46125000,
chr21:45950000-45975000~~chr21:46100000-46125000,
chr21:45975000-46000000~~chr21:46100000-46125000,
chr21:46000000-46025000~~chr21:46100000-46125000,
chr21:46100000-46125000~~chr21:46200000-46225000,