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Basic information

CohesinDB ID: CDBP00421432

Locus: chr21-46108827-46114343

Data sourse: ENCSR000BLD, ENCSR230ZWH, GSE72082, ENCSR000BLY, GSE105028, GSE131606, GSE25021, ENCSR000BTU, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE206145-NatGen2015, GSE106870, GSE145327, GSE118494, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR000EHX, GSE97394, ENCSR167MTG, ENCSR054FKH, ENCSR153HNT, GSE68388

Cell type: MCF-7, H1-hESC, RPE, Fibroblast, HCT-116, Hela-Kyoto, Hep-G2, CVB-hiPSC, Ishikawa, HUES64, IMR-90, K-562, SK-N-SH, CVI-hiPSC, Liver, HSPC, HuCC-T1, H9-hESC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 12% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.800

Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 84% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 23%, "15_Quies": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, SOX2, XBP1, FOXA1, ZNF28, SFMBT1, ATF3, CHD7, PRDM1, TP63, TEAD1, TRIM28, ESR1, OCA2, USF2, CTCF, E2F1, TFAP2C, GLIS1, NANOG, CHD8, ZNF263, POU5F1, TOP2A, MYCN, ZBTB48, ZNF300, ERG, OGG1, MYC, EZH1, RAD21, GRHL3, KLF12, GABPA, APC, STAT3, XRCC5, DNMT3B, NR3C1, HNRNPL, EZH2, SPI1, SSRP1, HCFC1R1, RUNX1, SMC1A, NKX2-2, ZFX, SMAD3, TET2, ERG3, TWIST1, CREBBP, ZNF384, NOTCH1, ZBTB2, IRF2, RUNX2, ARNT, ZBTB10, ZNF48, ZEB2, SP2, CHD1, FOS, MED1, KDM6B, ZNF680, PIAS1, SUPT16H, NCOA1, SETDB1, USF1, NR4A1, RBM25, HNRNPLL, MBD2, AATF, SMC3, STAG1, TRP47, CBFA2T2, AGO1, FOXA2, CBX3, ZNF600, WT1, ZBTB33, CDK9, MPHOSPH8, KDM1A, YY1, RELA, TARDBP, AHR, SP140, ZIC2, HIF1A, TCF4, TAL1, ZNF143, PLAG1, GFI1B, NCOA3, NR2F1, KDM5B, TP53, AR, YAP1, EGLN2, HEXIM1, HSF1, BRD4, MAZ, ZNF316

Target gene symbol (double-evidenced CRMs): PCBP3,SLC19A1,COL6A2,ADARB1,LSS,COL6A1,FAM207A,MCM3AP-AS1,COL18A1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 1198

Number of somatic mutations (non-coding): 313

Related genes and loops

Related gene: ENSG00000160256, ENSG00000197381, ENSG00000182871, ENSG00000173638, ENSG00000183570, ENSG00000142156, ENSG00000142173, ENSG00000160285, ENSG00000215424,

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Deatailed information for cohesin site CDBP00421432