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Basic information

CohesinDB ID: CDBP00421433

Locus: chr21-46114890-46141044

Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, GSE116868, ENCSR000BLY, GSE105028, GSE131606, GSE25021, GSE165895, ENCSR000EFJ, ENCSR000BTU, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE206145-NatGen2015, GSE135093, GSE120943, ENCSR703TNG, GSE118494, ENCSR338DUC, GSE98367, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR000EHX, ENCSR000BTQ, ENCSR167MTG, GSE110061, ENCSR000HPG, GSE111913, ENCSR153HNT, GSE68388, GSE38411

Cell type: Liver, HuCC-T1, H9-hESC, RPE, Fibroblast, Ishikawa, IMR-90, K-562, BCBL-1, DKO, HFFc6, H1-hESC, Monocytes, MB157, SK-N-SH, RT-112, Macrophage, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 16% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.756

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: TES,Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 84% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 18%, "4_Tx": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, TRIM25, NME2, FOXA1, ZBTB7B, HDGF, THAP1, TEAD1, LMO2, HDAC8, E4F1, ZNF157, PAX8, ZNF407, E2F4, ZNF528, JARID2, ZNF263, POU5F1, TOP2A, CTBP1, STAT1, ERG, ZBTB21, SMARCA4, RFX1, TOP1, ZNF8, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, KLF17, GATA2, MXD3, SIX2, FLI1, NR2C2, MXI1, HCFC1R1, RUNX1, HDAC1, IRF3, ZNF658, TET2, ZNF473, PRDM10, ZXDC, ZBTB2, ZBTB10, ATF2, SATB1, SP2, GMEB1, PIAS1, C11orf30, EVI1, ARID2, IKZF5, RBM25, MBD2, NFATC3, CBFA2T2, CBX3, ZNF207, CREM, CHD2, PAF1, WT1, JUNB, NEUROD1, MCM3, ZFP36, TCF4, ZNF311, PLAG1, KLF4, BCL11B, ZBTB6, EGR2, ELF3, RXR, EGLN2, ZNF366, HSF1, ZBTB26, SCRT1, ZNF316, FOSL1, XBP1, PBX2, ATF3, WDHD1, CBFB, TP63, ZSCAN4, MITF, MAF, ELF1, RBM39, SNAI2, CTCF, JUN, MNT, SIX5, ZNF776, TFAP2C, RBPJ, YBX1, ZSCAN21, ZBTB17, ZBTB48, MTA2, ZNF317, DDX5, PBX1, ZNF2, FOXP2, RXRA, PRDM14, NR3C1, ESRRA, KMT2A, KLF8, ARHGAP35, GRHL2, EBF3, SSRP1, ZNF747, ZNF770, ZNF18, ARNT, NFIB, DAXX, ZNF48, ZEB2, PBX3, NCAPH2, DIDO1, KLF9, TBX5, USF1, BCL11A, SP1, NKX2-5, ZNF479, ATF7, CTBP2, GLIS2, SMC3, STAG1, TRP47, SAFB, AGO1, MTA3, ESR2, ZKSCAN1, BCL3, KDM1A, ZIC2, GATA3, TAL1, NRIP1, ZNF143, MTA1, AGO2, ZNF141, TP53, ZNF334, EGR1, TFIIIC, RNF2, BRD4, JUND, ZSCAN23, ZNF468, PGR, PATZ1, UBTF, BMI1, ZNF444, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, KLF1, SOX4, E2F6, TRIM24, GTF2F1, GLIS1, ZSCAN5D, ZBTB1, ZSCAN5A, ERG2, SP4, HIC1, HOXC5, OGG1, MYC, GABPA, STAT3, DNMT3B, SRSF3, EZH2, PCBP1, HDAC2, GATAD2B, NCOA2, ZNF554, ETV5, BCL6, ERG3, CREBBP, RARA, TAF15, HMGB2, CDK8, ZEB1, ZNF264, ZMYM3, SUPT16H, RBM22, HNF4A, REST, HNRNPLL, AATF, HDAC6, ZNF30, ZNF662, ZFP14, RELA, TARDBP, MAX, NR2F1, KDM5B, PKNOX1, MYOD1, AR, ZNF445, ZNF324, HEXIM1, ZNF280D, AHR, FOSL2, MBD3, E2F7, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, ZNF90, ZNF274, NFIC, INSM2, CTCFL, ZBTB5, KLF14, ZNF736, ZNF629, ZNF506, TRIM28, USF2, TCF12, BAF155, EP300, GATA6, RAD51, ZNF512B, E2F1, ZNF175, EHMT2, CHD8, BRD1, SRC, MYCN, RUNX1T1, ID3, ZNF649, ARID3A, RAD21, GRHL3, APC, XRCC5, ZNF639, FEZF1, HES1, MRTFB, MYF5, ATF1, PTBP1, CBX1, SIRT6, ZFX, ZNF534, ZNF454, SMAD3, TWIST1, RUNX2, GATA4, ZNF184, PBX4, NRF1, NR2C1, CHD1, FOS, MED1, KDM6B, ZNF558, SCRT2, ZNF3, L3MBTL2, SETDB1, ZBTB7A, TCF3, ZNF283, FOXA2, ZNF600, ZBTB33, CDK9, HOXB13, YY1, ZNF148, SP140, HIF1A, GATA1, HAND2, SP7, NCOA3, NR2F2, BHLHE40, ZNF579, ZBTB42, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): PCBP3,COL18A1,FAM207A,COL6A2,ADARB1,COL6A1,FTCD,MCM3AP-AS1,LSS,SLC19A1

Function elements

Human SNPs: Waist-to-hip_ratio_adjusted_for_BMI

Number of somatic mutations (coding): 4788

Number of somatic mutations (non-coding): 1255

Related genes and loops

Related gene: ENSG00000160256, ENSG00000197381, ENSG00000182871, ENSG00000173638, ENSG00000183570, ENSG00000142156, ENSG00000142173, ENSG00000160282, ENSG00000160285, ENSG00000215424,

eachgene

Deatailed information for cohesin site CDBP00421433