Deatailed information for cohesin site CDBP00421434

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  • Basic information
  • CohesinDB ID: CDBP00421434
  • Locus: chr21-46141781-46148753
  • Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
  • Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, Transformed-RPE1, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, HeLa, CNCC-WT33iPSC, TC-71, Neutrophil, GM18951
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 80% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.156
  • Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: True
  • Genomic location: TSS,TES,Intragenic
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 84% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 23%, "2_TssAFlnk": 15%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: NFIA, FOSL1, TRIM25, ZNF391, PATZ1, FOXA1, RBFOX2, RXRB, PBX2, ZNF28, ZNF596, ZFHX2, HNRNPK, KDM3A, UBTF, HDGF, ATF3, INSM2, THRB, THAP1, ZNF362, CHD7, CTCFL, RUNX3, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, PAX5, ZSCAN4, MITF, ZNF467, MAF, ZNF629, TEAD1, ZNF121, TRIM28, RBM39, KLF6, NFE2L2, BCLAF1, COBLL1, ESR1, ZNF217, FUS, ZNF524, CTCF, JUN, BAF155, MNT, SOX5, DPF2, E2F6, TRIM24, RFX5, SOX6, E2F4, ZNF528, SMC1, TEAD4, GTF2F1, GATAD2A, TFAP2C, EHMT2, RBPJ, GLIS1, MLX, BRD1, ZSCAN5D, MYCN, ZNF263, RUNX1T1, POU5F1, CTBP1, MTA2, ZBTB17, ZBTB48, ZSCAN21, STAT1, ZSCAN5A, ZNF134, SRF, SAP130, NBN, ARID3A, GATAD1, TBP, ERG, HOXC5, OGG1, ZNF341, ZBTB8A, MYC, SMARCA4, ZNF2, HOMEZ, FOXP2, RAD21, GRHL3, ARID1B, ZNF671, NKX2-1, FOXK2, GABPA, STAT3, XRCC5, ZNF614, IKZF1, RCOR1, DNMT3B, HNRNPH1, NR2F6, ZNF639, ESRRA, CEBPB, HNRNPL, KMT2A, CREB1, TBL1XR1, KLF8, FEZF1, GRHL2, EBF3, GABPB1, ZHX2, MIXL1, TFE3, KLF17, PCBP1, HDAC2, MXD3, DRAP1, ZGPAT, SMARCA5, HCFC1R1, NFIL3, ATF1, PTBP1, ETV5, CC2D1A, RUNX1, THAP11, SMC1A, BCL6, HDAC1, SIRT6, CBX1, SIN3A, ZFX, ZNF534, FIP1L1, SOX13, SMAD3, ZNF654, ZNF770, TRIM22, ZNF18, ZNF549, SMARCC1, ZBTB2, ZNF35, PRPF4, IRF2, ZNF169, TAF15, NFYC, ZNF384, RARA, OSR2, BRD9, ZNF184, SP3, NRF1, ZBTB10, ZNF48, PRDM9, ZEB2, SMAD4, FOXM1, NCAPH2, SP2, FOS, ZNF10, HMGXB4, GMEB1, TEAD3, ZEB1, ZNF680, SCRT2, ZNF3, NCOA1, L3MBTL2, SETDB1, KLF16, RBM22, USF1, BCL11A, NIPBL, HNF4A, ARID2, IKZF5, ZBTB7A, REST, POU2F3, ATF7, ASH2L, ZHX1, HNRNPLL, AFF1, GLIS2, TCF3, BCOR, PHIP, AATF, SMC3, STAG1, STAG2, MLLT1, TRP47, PPARG, AGO1, FOXA2, MTA3, CBX3, CREM, ZNF600, ZNF692, MIER2, WT1, ZBTB33, MEF2C, ZNF580, ZKSCAN1, HOXB13, KDM1A, YY1, RELA, TARDBP, NEUROD1, BRG1, SP140, ZIC2, SKIL, ZFP36, OTX2, GATA3, MAF1, MAX, GATA1, AGO2, MTA1, ZNF143, PLAG1, ZFP69B, CEBPG, SP7, GFI1B, TCF7L2, TP53, PKNOX1, ZNF687, ZNF334, EGR2, PHOX2B, BRD2, ELF3, KAT8, NFKBIZ, AR, ARID4B, BHLHE40, ZNF579, ZBTB40, ZNF324, ZNF366, EGR1, RB1, TFIIIC, ZBTB26, RNF2, BRD4, JUND, SCRT1, CLOCK, MAZ, ZSCAN23, ZNF24, AHR
  • Target gene symbol (double-evidenced CRMs): PRMT2,PCNT,POFUT2,COL6A1,PCBP3,C21orf58,YBEY,FTCD,LSS
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 460
  • Number of somatic mutations (non-coding): 115
  • Related genes and loops
  • Related gene: ENSG00000186866, ENSG00000183570, ENSG00000142156, ENSG00000160282, ENSG00000160285, ENSG00000182362, ENSG00000160298, ENSG00000160299, ENSG00000160310,
  • Related loop: chr21:40475000-40500000~~chr21:46125000-46150000, chr21:45269718-45271115~~chr21:46142948-46144578, chr21:45725000-45750000~~chr21:46125000-46150000, chr21:45950000-45975000~~chr21:46125000-46150000, chr21:45969912-45971939~~chr21:46146852-46148242, chr21:45969927-45971657~~chr21:46143028-46144654, chr21:45972821-45974610~~chr21:46143050-46144647, chr21:45972910-45974653~~chr21:46143028-46144654, chr21:45975000-46000000~~chr21:46125000-46150000, chr21:46025000-46050000~~chr21:46125000-46150000, chr21:46142465-46144615~~chr21:46285004-46287523, chr21:46143023-46144677~~chr21:46639346-46640584, chr21:46146626-46148368~~chr21:46324586-46327028, chr21:46146642-46148386~~chr21:46324608-46326836, chr21:46146852-46148242~~chr21:46209838-46211680, chr21:46152443-46154288~~chr21:46209880-46211539, chr21:46152495-46154271~~chr21:46639226-46640751,
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