Deatailed information for cohesin site CDBP00421435

Check detailed explainations here

  • Basic information
  • CohesinDB ID: CDBP00421435
  • Locus: chr21-46149160-46156934
  • Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, GSE120943, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR338DUC, GSE115248, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
  • Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, Lymphoblast, GM12878, GM12891, GM2588, GBM39, HUES9, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, A-549, HUVEC, HCAEC, GM19238, Neutrophil, GM18951
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 65% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.244
  • Subunit: SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: True
  • Genomic location: TSS,TES
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 84% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "7_Enh": 23%, "5_TxWk": 22%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: NFIA, TRIM25, FOXA1, RXRB, KDM3A, ZBTB7B, HDGF, THAP1, PAX5, TEAD1, HDAC8, ZNF561, E4F1, SOX5, DEK, E2F4, RFX3, GATAD2A, POU5F1, ZNF263, CTBP1, ERF, STAT1, SAP130, ERG, SMARCA4, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, HCFC1, DRAP1, MXI1, RUVBL2, RUNX1, CEBPA, HDAC1, REPIN1, TET2, ZNF654, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ELK1, ZBTB10, TFDP1, SP2, SMARCB1, GMEB1, PML, SMAD1, C11orf30, STAT5A, IKZF5, MBD2, ETV4, NFATC3, CBFA2T2, CBX3, ZNF207, CREM, CHD2, WT1, MEF2C, NEUROD1, JUNB, ZFP36, PLAG1, ZFP69B, ZNF281, IRF5, EGR2, ELF3, RBM14, ARID4B, ZBTB26, HSF1, NCOR1, ILF3, ZNF316, FOSL1, HNF1A, KDM4B, PBX2, HNRNPK, THRB, ATF3, ZFP64, ZNF273, ZNF467, CDC5L, ELF1, RBM39, CTCF, JUN, L3MBTL4, MNT, DPF2, TFAP2C, RBPJ, MLX, MTA2, ZBTB17, ZBTB48, ZSCAN21, NONO, SRF, NBN, HOMEZ, FOXP2, RXRA, MIER3, HNRNPH1, LEF1, VDR, NR3C1, ESRRA, KMT2A, TBL1XR1, GRHL2, SMARCA5, NFIL3, CC2D1A, THAP11, SOX13, ZMIZ1, ZNF18, BACH1, ZNF48, ZEB2, ETV6, NCAPH2, HMGXB4, TEAD3, U2AF1, TBX5, USF1, SP1, BCL11A, NKX2-5, ATF7, ASH2L, CTBP2, GLIS2, SMC3, STAG2, STAG1, MLLT1, TRP47, SAFB, AGO1, MTA3, MAFF, ZNF580, ZKSCAN1, KDM1A, BRG1, ZIC2, TAL1, ZNF143, AGO2, MTA1, TP53, ZNF334, PHF5A, BRD2, KAT8, EGR1, RB1, TFIIIC, RNF2, JUND, BRD4, CUX1, PGR, PATZ1, LEO1, UBTF, TFAP4, SIN3B, BMI1, CHD7, ZNF444, MXD4, SMARCE1, KLF6, NFE2L2, ESR1, ZNF524, KLF1, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZSCAN5A, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ZNF671, ARID1B, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, ZNF652, PHF8, PCBP1, HDAC2, GATAD2B, ETV5, BCL6, SIN3A, ERG3, RARA, ZNF35, ZNF384, NFYC, TAF15, SMAD4, CBFA2T3, ZEB1, NCOA1, SREBF2, RBM22, MAFK, HNF4A, NR4A1, REST, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, PPARG, ZNF692, ZNF30, ZNF574, TCF7, FOXO3, RELA, TARDBP, ZNF282, SKIL, MAX, ZNF592, GFI1B, TCF7L2, NR2F1, KDM5B, AR, DMAP1, AHR, FOSL2, HMG20A, HMGN3, SUZ12, RBFOX2, ZFHX2, NFIC, CTCFL, ZBTB5, PRDM1, ZNF629, KLF5, TRIM28, ETV1, RCOR2, USF2, TCF12, EP300, SOX6, SMC1, TEAD4, FOXA3, ZNF175, MYCN, RUNX1T1, ID3, GATAD1, ARID3A, RAD21, GRHL3, APC, ZNF614, XRCC5, ZNF639, TFE3, HBP1, SREBF1, ZGPAT, ATF1, PTBP1, CBX1, MAFG, SMC1A, SIRT6, FIP1L1, ZFX, SMAD3, NSD2, IRF2, PRPF4, BRD9, GATA4, ZNF184, NRF1, FOS, SUPT5H, CHD1, TGIF2, MED1, CEBPD, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, PHF20, ZBTB7A, CCNT2, PHIP, TCF3, SKI, PAX7, KLF13, FOXA2, RBBP5, E2F8, MIER2, ZNF600, ZBTB33, YY1, ZNF148, SP140, ZNF740, GATA1, CEBPG, NR2F2, NFKBIZ, BHLHE40, TAF1, ZBTB40, ZBTB42, MYNN, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): PRMT2,COL6A1,LSS,FTCD,SPATC1L,PCBP3
  • Function elements
  • Human SNPs: Waist_circumference_adjusted_for_body_mass_index
  • Number of somatic mutations (coding): 1172
  • Number of somatic mutations (non-coding): 285
  • Related genes and loops
  • Related gene: ENSG00000183570, ENSG00000142156, ENSG00000160282, ENSG00000160284, ENSG00000160285, ENSG00000160310,
  • Related loop: chr21:40475000-40500000~~chr21:46125000-46150000, chr21:45269718-45271115~~chr21:46142948-46144578, chr21:45725000-45750000~~chr21:46125000-46150000, chr21:45950000-45975000~~chr21:46125000-46150000, chr21:45969912-45971939~~chr21:46146852-46148242, chr21:45969927-45971657~~chr21:46143028-46144654, chr21:45972821-45974610~~chr21:46143050-46144647, chr21:45972910-45974653~~chr21:46143028-46144654, chr21:45975000-46000000~~chr21:46125000-46150000, chr21:46025000-46050000~~chr21:46125000-46150000, chr21:46142465-46144615~~chr21:46285004-46287523, chr21:46143023-46144677~~chr21:46639346-46640584, chr21:46146626-46148368~~chr21:46324586-46327028, chr21:46146642-46148386~~chr21:46324608-46326836, chr21:46146852-46148242~~chr21:46209838-46211680, chr21:46152443-46154288~~chr21:46209880-46211539, chr21:46152495-46154271~~chr21:46639226-46640751,
eachgene