- Basic information
- CohesinDB ID: CDBP00421444
- Locus: chr21-46186833-46187560
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Data sourse: GSE206145, GSE206145-NatGen2015, GSE86191
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Cell type: RPE, Fibroblast, HCT-116
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.967
- Subunit: Rad21
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
84% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 86%,
"4_Tx": 5%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, FOSL1, PGR, ZNF660, MEIS2, PATZ1, FOXA1, RBFOX2, LEO1, PBX2, MLL4, RXRB, ZFHX2, TFAP4, OGG1, HDGF, ATF3, INSM2, ZFP64, CTCFL, CHD7, ZNF444, ZNF189, SMARCE1, MITF, CDC5L, ZNF629, TEAD1, TRIM28, ELF1, ZNF573, RBM39, NFE2L2, RCOR2, ESR1, ZNF217, SAP30, HDAC8, USF2, CTCF, TCF12, JUN, BAF155, E4F1, EP300, MNT, KLF1, SOX5, DPF2, SOX4, E2F6, RFX5, SOX6, E2F4, DEK, RAD51, DDX20, E2F1, ZNF528, SMC1, TEAD4, FOXA3, GTF2F1, GATAD2A, PDX1, TFAP2C, GLIS1, BRD1, ZSCAN5D, MYCN, ZNF263, RUNX1T1, ID3, CTBP1, MTA2, ZBTB17, ZSCAN21, ZBTB48, ZSCAN5A, SAP130, NBN, ARID3A, ERG2, SP4, HNF4G, ERG, HOXC5, MIER1, SMARCC2, ZNF341, MYC, ETS1, SMARCA4, TSHZ1, ARID1B, RAD21, HOMEZ, FOXP2, GRHL3, NKX2-1, FOXK2, STAT3, ZNF614, XRCC5, IKZF1, NFE2, RCOR1, ZNF639, NR2F6, LEF1, ARNTL, NR3C1, ESRRA, CEBPB, DNMT3B, HNRNPL, SRSF3, CREB1, CCAR2, TBL1XR1, EZH2, GRHL2, EBF3, ZHX2, SPI1, MIXL1, KLF17, HDAC2, INTS13, GATA2, ZNF644, SSRP1, MXD3, FLI1, HCFC1, ZGPAT, MXI1, MRTFB, NCOA2, ZNF554, ATF1, PTBP1, RUNX1, MAFG, SMC1A, HDAC1, CEBPA, CBX1, SIRT6, SIN3A, ZFX, SOX13, SMAD3, ZNF770, ERG3, TET2, SMARCC1, PRDM10, TWIST1, NSD2, RARA, ZNF384, ZNF35, ZXDC, TAF15, BRD9, GATA4, OSR2, GR, ZNF184, PBX4, ARNT, NRF1, BACH1, ATF2, ZEB2, SMAD4, ETV6, CBFA2T3, PBX3, FOS, SUPT5H, CHD1, SMARCB1, SP2, MED1, TEAD3, ZEB1, CEBPD, HNRNPH1, VEZF1, ZNF3, C11orf30, L3MBTL2, NCOA1, EVI1, TBX5, KLF16, RBM22, MAFK, BCL11A, SP1, USF1, HNF4A, IKZF5, REST, ZBTB7A, ARID1A, ATF7, ZHX1, HNRNPLL, CTBP2, PHIP, AFF1, BCOR, MBD2, PRDM6, AATF, SMC3, MLLT1, NFATC3, SKI, ZNF394, TRP47, CBFA2T2, ZNF283, PPARG, FOXA2, MTA3, CREM, CBX3, PAF1, CHD2, ZNF600, ZNF692, E2F8, MAFF, WT1, RBBP5, ZNF574, ZBTB33, HOXB13, ZKSCAN1, ZNF318, KDM1A, YY1, RELA, ZNF148, JUNB, NEUROD1, AHR, SP140, ZFP36, SKIL, TCF4, ZIC2, GATA3, BATF, KLF15, TAL1, MAX, GATA1, ZNF143, MTA1, AGO2, HAND2, PLAG1, ZNF592, SP7, GFI1B, NR2F2, ZNF83, ZNF281, NR2F1, TCF7L2, NEUROG2, TP53, PKNOX1, ZNF687, ZNF334, ZSCAN22, MYOD1, EGR2, ELF3, BRD2, PHF5A, ARID4B, BHLHE40, AR, ZBTB40, ZNF324, ZBTB42, EGR1, ZNF366, ZBTB26, NCOR1, RNF2, JUND, BRD4, ILF3, MYNN, CLOCK, MAZ, SCRT1, ZNF24, ZNF316, FOSL2
- Target gene symbol (double-evidenced CRMs): LSS,SPATC1L
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 5
- Related genes and loops