- Basic information
- CohesinDB ID: CDBP00421448
- Locus: chr21-46200854-46202398
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Data sourse: GSE38395, GSE206145-GSE177045, ENCSR230ZWH, GSE67783, GSE86191, GSE165895, ENCSR917QNE, GSE76893, GSE206145, GSE206145-NatGen2015, ENCSR635OSG, ENCSR153HNT, GSE131606, GSE131577
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Cell type: MCF-7, RPE, Fibroblast, HL-60, HCT-116, DKO, hLCL, K-562, Liver, HSPC, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 5% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.878
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
84% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"5_TxWk": 53%,
"4_Tx": 42%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOSL1, PGR, CBFA2T2, FOXA2, BRD3, ZNF263, TOP2A, SOX13, ASH1L, WT1, DUX4, ESR2, FOXA1, SMAD3, ZBTB33, ERG3, ERG2, HOXB13, ZFHX2, RELA, HDGF, ZNF384, NFIC, ZNF362, PBX4, RXRA, GATA3, ZNF8, MAX, NR2C1, FOS, MITF, TLE3, CEBPG, CEBPB, NR3C1, NR2F2, ZNF264, ZNF3, ESR1, L3MBTL2, GRHL2, USF2, EGR2, ZNF22, RBM22, USF1, SP1, BHLHE40, MNT, E2F6, TRIM24, ZNF146, EGR1, RAD51, NR2C2, SMARCA5, E2F1, MAZ, IRF9, ZZZ3, TFAP2C
- Target gene symbol (double-evidenced CRMs): LSS,PCBP3,COL6A2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 52
- Number of somatic mutations (non-coding): 7
- Related genes and loops