- Basic information
- CohesinDB ID: CDBP00421451
- Locus: chr21-46217086-46221336
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Data sourse: GSE67783, GSE72082, GSE86191, GSE111913, ENCSR000BLS, GSE206145, GSE206145-NatGen2015, ENCSR153HNT, GSE83726
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Cell type: RPE, Fibroblast, HCT-116, RH4, Hep-G2, RT-112, K-562, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.911
- Subunit: SA1,Rad21,SA2
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
84% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"4_Tx": 51%,
"5_TxWk": 32%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, TRP47, AGO1, MYCN, SIRT6, EBF1, ZFX, ZNF600, MTA2, ZBTB48, WT1, FOXA1, TET2, RBFOX2, LEO1, ZFHX2, RELA, HDGF, ZNF384, TAF15, ATF3, MYC, SP140, GRHL3, BACH1, PAX5, SUPT5H, AGO2, IKZF1, DNMT3B, FOS, KDM5B, ZNF687, ESR1, ZNF334, GABPB1, RBM14, RBM22, CTCF, SPI1, DPF2, REST, BRD4, SMARCA5, RELB, MAZ, AATF, ETV5, AHR
- Target gene symbol (double-evidenced CRMs): PCBP3,LSS,COL6A2
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 140
- Number of somatic mutations (non-coding): 30
- Related genes and loops