Deatailed information for cohesin site CDBP00421483

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  • Basic information
  • CohesinDB ID: CDBP00421483
  • Locus: chr21-46284943-46285049
  • Data sourse: GSE120943, GSE98367
  • Cell type: Monocytes, Macrophage
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 0% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.978
  • Subunit: SMC1
  • CTCF binding site: non-CTCF CTCF motif: False
  • Genomic location: TSS
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: False Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 88% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): False
  • Chromatin annotation: "2_TssAFlnk": 32%, "7_Enh": 31%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, PAX5, ZNF320, TEAD1, ZNF121, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, ZNF577, E4F1, ARID5B, ZNF157, SOX5, ZNF75A, DEK, E2F4, ZNF528, RFX3, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, BRD3, TOP2A, POU5F1, CTBP1, ZMYND11, ERF, STAT1, SAP130, ERG, ZBTB21, NFKB2, ZBTB8A, EZH1, SMARCA4, RFX1, TOP1, DNMT1, FOXK2, ZNF8, UBN1, ZNF398, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, DDX21, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, NR2C2, HCFC1, RELB, EP400, RUVBL2, RUNX1, HDAC1, CEBPA, NKX2-2, IRF3, REPIN1, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ZXDC, TFDP1, ZBTB10, ELK1, ATF2, SATB1, FOXM1, SP2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, C11orf30, EVI1, MBD1, STAT5A, GSPT2, ARID2, IKZF5, OVOL3, RBM25, ZSCAN31, AFF1, MBD2, ELL2, ZNF704, HMGB1, ETV4, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, PAF1, SS18, NFATC1, ZSCAN16, WT1, MEF2C, CREB3L1, JUNB, NEUROD1, ZFP36, TCF4, BATF, MAF1, SPIB, PLAG1, KLF4, ZFP69B, BCL11B, ZNF784, ZBTB6, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, ZNF101, ZNF221, SRSF4, PBX2, ZNF596, HNRNPK, ATF3, THRB, ZFP64, RUNX3, CBFB, TP63, ZSCAN4, MITF, ZNF467, JMJD1C, INTS11, MAF, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, JUN, TAF3, CTCF, L3MBTL4, LMO1, ZBTB20, MNT, DPF2, RYBP, SIX5, IRF4, ZNF423, ZNF350, ZNF280A, PDX1, TFAP2C, RBPJ, MLX, ZNF239, MTA2, ZBTB17, ZBTB48, ZSCAN21, NONO, SRF, DDX5, NBN, ZNF329, PBX1, ZKSCAN2, KDM4A, HOMEZ, ZNF2, TSHZ1, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, CCAR2, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, SSRP1, ZNF146, ZSCAN29, SMARCA5, NFIL3, THAP11, CTNNB1, EZH2phosphoT487, LDB1, AFF4, SOX13, POU4F2, ZNF770, ZNF513, ZMIZ1, ZNF18, CEBPZ, SP3, ARNT, BACH1, NFIB, ZNF48, PRDM9, ZEB2, NFYA, PBX3, NCAPH2, ZNF10, ETV6, HMGXB4, TEAD3, DIDO1, ZXDB, ZNF680, U2AF1, TAF7, KLF9, USF1, BCL11A, SP1, ZNF479, ATF7, ASH2L, CTBP2, GLIS2, ZNF623, SMC3, STAG1, MLLT1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MAFF, ZNF580, BCL3, KLF7, ZKSCAN1, KDM1A, ZNF266, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, ZNF143, AGO2, MTA1, ZNF768, TP53, ZNF334, NFKB1, ZSCAN22, ZNF140, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, SPIN1, CUX1, ZSCAN23, ZNF468, PGR, CBX5, PATZ1, LEO1, UBTF, TFAP4, SIN3B, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, MZF1, RLF, KLF6, NFE2L2, SAP30, ESR1, ZNF217, ZNF524, SND1, KLF1, SOX9, ZNF260, SOX4, E2F6, TRIM24, PRKDC, GTF2F1, GLIS1, POU2F2, ZSCAN5D, ZNF778, KDM4C, ZBTB1, ZSCAN5A, ELK4, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, ETS1, MYC, PHF21A, KLF12, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, GFI1, DNMT3B, INO80, SRSF3, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, RBP2, GATAD2B, NCOA2, ZNF76, ETV5, BCL6, SIN3A, ZFP37, ERG3, MYBL2, CREBBP, RARA, NFYC, ZNF35, TAF15, ZNF384, SMAD4, ZNF518A, CDK8, CSNK2A1, ZEB1, SPDEF, ZNF264, SUPT16H, NCOA1, SREBF2, RBM22, MAFK, NR4A1, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, ZNF816, PPARG, TBL1X, ZNF692, GTF2B, ZNF30, ZNF574, TCF7, FOXO3, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF592, GFI1B, TCF7L2, NR2F1, KDM5B, ZNF791, NEUROG2, PKNOX1, MYOD1, AR, ZNF445, KMT2D, ZBTB16, YAP1, ZNF324, HEXIM1, DMAP1, AHR, MBD3, FOSL2, ZNF391, HMG20A, ZSCAN5C, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, SFMBT1, INSM2, NFIC, CTCFL, PRDM1, KLF14, MECOM, ZNF736, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, MLL, USF2, ZFP91, TCF12, BAF155, EP300, GATA6, PRDM4, GLI4, SOX6, CREB3, RAD51, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, ATRX, CHD8, BRD1, MYCN, SRC, RUNX1T1, ID3, CDK7, GATAD1, GMEB2, ARID3A, ASCL1, MIER1, ZNF341, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, ZNF501, ZNF85, FEZF1, TFE3, EHF, HBP1, IRF1, ZNF664, SREBF1, ZGPAT, MRTFB, ZC3H11A, ATF1, PTBP1, ZNF45A, SMC1A, CBX1, SIRT6, ZNF335, ZFX, FIP1L1, ZNF534, SMAD3, NMYC, TWIST1, IRF2, PRPF4, NOTCH1, BRD9, RUNX2, ZSCAN30, GATA4, CDK6, GR, ZNF184, OSR2, PBX4, NRF1, NR2C1, SUPT5H, FOS, CHD1, TGIF2, MED1, KDM6B, MYB, CEBPD, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, PHIP, TCF3, SKI, NELFA, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ASXL1, ZNF610, SP140, BRCA1, HIF1A, OTX2, ZNF449, GATA1, CEBPG, SP7, NCOA3, NR2F2, ZNF512, ZNF687, ZNF213, ZNF837, ZNF843, BHLHE40, NFKBIZ, TAF1, ZNF579, ZBTB40, MYNN, CLOCK, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): PCNT,YBEY,C21orf58,FTCD
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 14
  • Number of somatic mutations (non-coding): 7
  • Related genes and loops
  • Related gene: ENSG00000160282, ENSG00000182362, ENSG00000160298, ENSG00000160299,
  • Related loop: chr21:46142465-46144615~~chr21:46285004-46287523, chr21:46284828-46287850~~chr21:46324624-46326392, chr21:46284891-46287117~~chr21:46325193-46327052, chr21:46284913-46287579~~chr21:46323099-46326350, chr21:46284994-46287562~~chr21:46323170-46326814, chr21:46285004-46287523~~chr21:46324190-46326305, chr21:46285202-46287572~~chr21:46324782-46326051, chr21:46285204-46287304~~chr21:46324596-46326067, chr21:46285206-46287083~~chr21:46324674-46326343, chr21:46285212-46287543~~chr21:46321861-46326303, chr21:46285216-46286892~~chr21:46324785-46326845, chr21:46285222-46287087~~chr21:46324856-46327070, chr21:46285272-46287549~~chr21:46324181-46326111,
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