- Basic information
- CohesinDB ID: CDBP00421486
- Locus: chr21-46289414-46300495
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Data sourse: GSE206145-GSE177045, GSE72082, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE25021, GSE131606, GSE165895, GSE115602, GSE93080, GSE143937, GSE67783, ENCSR000BKV, GSE86191, GSE76893, GSE101921, GSE206145-NatGen2015, GSE120943, ENCSR703TNG, GSE116344, ENCSR338DUC, GSE98367, ENCSR879KXD, ENCSR000BLS, GSE206145, ENCSR167MTG, GSE111913, ENCSR054FKH, ENCSR153HNT, GSE68388, GSE83726, GSE131577
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Cell type: RH4, HuCC-T1, H9-hESC, RPE, Fibroblast, K-562, DKO, HFFc6, Monocytes, GM12878, SK-N-SH, RT-112, Macrophage, MCF-7, HCT-116, HL-60, Hep-G2, HCAEC, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 14% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.789
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES,Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: False
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
88% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 37%,
"7_Enh": 13%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RELA, ZNF384, CEBPB, MAFG, TOP2A, PAF1, ZFX, ARNT, MAFF, C11orf30, TAL1, MAFK, NFE2, ZNF316
- Target gene symbol (double-evidenced CRMs): YBEY,C21orf58
- Function elements
- Human SNPs: 3-hydroxy-1-methylpropylmercapturic_acid_levels_in_smokers
- Number of somatic mutations (coding): 863
- Number of somatic mutations (non-coding): 123
- Related genes and loops
- Related gene:
ENSG00000182362,
ENSG00000160298,
- Related loop:
chr21:46142465-46144615~~chr21:46285004-46287523,
chr21:46284828-46287850~~chr21:46324624-46326392,
chr21:46284891-46287117~~chr21:46325193-46327052,
chr21:46284913-46287579~~chr21:46323099-46326350,
chr21:46284994-46287562~~chr21:46323170-46326814,
chr21:46285004-46287523~~chr21:46324190-46326305,
chr21:46285202-46287572~~chr21:46324782-46326051,
chr21:46285204-46287304~~chr21:46324596-46326067,
chr21:46285206-46287083~~chr21:46324674-46326343,
chr21:46285212-46287543~~chr21:46321861-46326303,
chr21:46285216-46286892~~chr21:46324785-46326845,
chr21:46285222-46287087~~chr21:46324856-46327070,
chr21:46285272-46287549~~chr21:46324181-46326111,