- Basic information
- CohesinDB ID: CDBP00421492
- Locus: chr21-46311471-46312825
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Data sourse: GSE67783, GSE86191, GSE98367, GSE206145-NatGen2015, GSE120943, ENCSR153HNT
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Cell type: Fibroblast, HCT-116, Monocytes, K-562, HSPC, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 2% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: SA1,Rad21,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: False
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
88% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 58%,
"4_Tx": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, NFATC3, CBFA2T2, FOXA2, POU5F1, MYCN, TOP2A, PAF1, ZFX, ZNF600, XBP1, ZNF263, ZBTB48, WT1, FOXA1, ERG3, SUZ12, RBFOX2, ERG2, LEO1, HOXB13, ZFHX2, NSD2, RELA, CREBBP, HDGF, ETS1, MYC, ZFP64, PRDM1, SP140, ARNT, PRDM9, KLF15, GABPA, SPIB, SUPT5H, PRDM14, AGO2, DNMT3B, HNRNPH1, ESRRA, CEBPB, ELF1, PIAS1, NFE2L2, STAG1, ESR1, KLF8, ZNF334, EGR2, CTCF, RBM22, KLF1, HDAC2, ZBTB40, GATA2, GATAD2B, ZNF366, EGR1, GLIS2, MAZ, EHMT2
- Target gene symbol (double-evidenced CRMs): C21orf58
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 110
- Number of somatic mutations (non-coding): 22
- Related genes and loops