- Basic information
- CohesinDB ID: CDBP00421493
- Locus: chr21-46313333-46319898
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Data sourse: ENCSR000BLD, ENCSR000BTQ, ENCSR000BTU, GSE118494, GSE67783, ENCSR000BKV, GSE72082, GSE86191, GSE110061, GSE111913, GSE105028, GSE206145-NatGen2015, ENCSR000ECE, GSE206145, ENCSR153HNT, ENCSR703TNG, GSE131606, GSE97394
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Cell type: MCF-7, H1-hESC, RPE, Fibroblast, HCT-116, Ishikawa, DKO, HUES64, RT-112, IMR-90, K-562, HSPC, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 6% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.856
- Subunit: SA1,Rad21,SA2,SMC1
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: False
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
88% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"5_TxWk": 48%,
"4_Tx": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, NFATC3, CBFA2T2, FOXA2, POU5F1, MYCN, TOP2A, PAF1, ZFX, ZNF600, XBP1, ZNF263, ZBTB48, WT1, FOXA1, ERG3, SUZ12, RBFOX2, ERG2, LEO1, HOXB13, ZFHX2, NSD2, RELA, CREBBP, HDGF, ETS1, MYC, ZFP64, PRDM1, SP140, ARNT, PRDM9, KLF15, GABPA, SPIB, SUPT5H, PRDM14, AGO2, DNMT3B, HNRNPH1, ESRRA, CEBPB, ELF1, PIAS1, NFE2L2, STAG1, ESR1, KLF8, ZNF334, EGR2, CTCF, RBM22, KLF1, HDAC2, ZBTB40, GATA2, GATAD2B, ZNF366, EGR1, GLIS2, MAZ, EHMT2
- Target gene symbol (double-evidenced CRMs): C21orf58,PCNT
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 719
- Number of somatic mutations (non-coding): 97
- Related genes and loops
- Related gene:
ENSG00000160298,
ENSG00000160299,
- Related loop:
chr21:46146626-46148368~~chr21:46324586-46327028,
chr21:46146642-46148386~~chr21:46324608-46326836,
chr21:46284828-46287850~~chr21:46324624-46326392,
chr21:46284913-46287579~~chr21:46323099-46326350,
chr21:46284994-46287562~~chr21:46323170-46326814,
chr21:46285004-46287523~~chr21:46324190-46326305,
chr21:46285202-46287572~~chr21:46324782-46326051,
chr21:46285204-46287304~~chr21:46324596-46326067,
chr21:46285206-46287083~~chr21:46324674-46326343,
chr21:46285212-46287543~~chr21:46321861-46326303,
chr21:46285216-46286892~~chr21:46324785-46326845,
chr21:46285222-46287087~~chr21:46324856-46327070,
chr21:46285272-46287549~~chr21:46324181-46326111,