Deatailed information for cohesin site CDBP00421494

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  • Basic information
  • CohesinDB ID: CDBP00421494
  • Locus: chr21-46320099-46321019
  • Data sourse: GSE143937, GSE67783, ENCSR000BKV, ENCSR000FAD, ENCSR000EGW, ENCSR879KXD, GSE206145-NatGen2015, ENCSR153HNT, GSE73207
  • Cell type: K-562, TF-1, Fibroblast, HSPC
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 2% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.956
  • Subunit: SMC3,Rad21,SA1
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: False Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 88% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "5_TxWk": 48%, "7_Enh": 24%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, ZNF426, ZNF675, NME2, FOXA1, RXRB, KDM3A, ZBTB7B, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, PAX5, TEAD1, ZNF121, E2F5, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, ZNF577, E4F1, ARID5B, SOX5, PYGO2, PAX8, ZNF407, E2F4, DEK, ZNF674, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, BRD3, TOP2A, CTBP1, ZMYND11, ERF, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, RFX1, TOP1, FOXK2, UBN1, ZNF398, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, RBM34, CREB1, BMPR1A, GABPB1, ELF4, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, HCFC1, MXI1, DRAP1, ZNF785, RELB, EP400, RUVBL2, RUNX1, HDAC1, NKX2-2, ZNF707, CEBPA, IRF3, REPIN1, TET2, TBX3, SP5, SMARCC1, PRDM10, ZBTB2, ELK1, TFDP1, ZBTB10, ATF2, SNIP1, SATB1, FOXM1, SP2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, C11orf30, EVI1, MBD1, STAT5A, IKZF5, ARID2, RBM25, AFF1, MBD2, ELL2, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, PAF1, SS18, NFATC1, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, TCF4, MAF1, PLAG1, KLF4, BCL11B, ZFP69B, ZKSCAN8, ZBTB6, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, HSF1, ZBTB26, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, KDM4B, PBX2, ZNF596, HNRNPK, ATF3, THRB, ZC3H8, ZFP64, RUNX3, CBFB, TP63, ZSCAN4, MITF, ZNF467, CDC5L, MAF, JMJD1C, INTS11, ELF1, RBM39, KLF10, SMAD5, FUS, CTCF, JUN, TAF3, L3MBTL4, MNT, LMO1, ZBTB20, DPF2, RYBP, SIX5, IRF4, DDX20, ZNF423, ZNF677, ZNF350, PDX1, TFAP2C, RBPJ, MLX, ZNF239, MTA2, ZBTB17, ZBTB48, ZSCAN21, NONO, SRF, DDX5, NBN, PHB2, PBX1, ONECUT1, ZNF2, KDM4A, HOMEZ, FOXP2, TSHZ1, RXRA, NKX3-1, PRDM14, LEF1, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, FOXK1, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, ZBTB14, SSRP1, ZNF146, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, LDB1, AFF4, SOX13, ZNF770, ZNF513, ZMIZ1, ZNF18, CEBPZ, SP3, ARNT, BACH1, NFIB, ZNF48, ZEB2, HMBOX1, NFYA, PBX3, NCAPH2, MAFB, ZNF10, HMGXB4, ZNF484, TEAD3, ZXDB, U2AF1, TAF7, KLF9, ZNF37A, USF1, BCL11A, TFAP2A, SP1, ZNF479, ATF7, ASH2L, GLIS2, PRDM6, ZNF623, SMC3, STAG1, MLLT1, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MEIS1, MAFF, ESR2, ZNF580, BCL3, ZKSCAN1, KDM1A, KLF7, BRG1, ZIC2, PCGF1, GATA3, KLF15, TAL1, NRIP1, ZNF143, AGO2, MTA1, TP53, ZNF645, ZNF334, ZSCAN22, NFKB1, PHOX2B, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, BRD4, JUND, CUX1, ZSCAN23, PGR, CBX5, FANCL, SOX2, PATZ1, LEO1, UBTF, TFAP4, SIN3B, BMI1, CHD7, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, MZF1, KLF6, MCM7, NFE2L2, SAP30, ESR1, ZNF217, ZNF524, KLF1, SOX9, SOX4, E2F6, TRIM24, RFX5, PRKDC, U2AF2, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ASH1L, ZSCAN5A, ELK4, ZNF224, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, KLF12, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, INO80, SRSF3, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, RBP2, GATAD2B, TAF9B, NCOA2, ZNF76, NFYB, ETV5, AHRR, BCL6, SIN3A, ERG3, MEF2A, MYBL2, RARA, CREBBP, ZNF384, NFYC, TAF15, ZNF35, SMAD4, ZNF518A, CBFA2T3, CDK8, CSNK2A1, ZEB1, ZNF264, ZMYM3, SUPT16H, NCOA1, SREBF2, ZNF22, RBM22, MAFK, NR4A1, HNF4A, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF574, YY2, FOXO3, ZFP14, RELA, TARDBP, CHAMP1, ZNF282, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, NEUROG2, ZNF791, PKNOX1, RUVBL1, MYOD1, T, AR, ZNF324, HEXIM1, ZNF395, AHR, DMAP1, MBD3, FOSL2, ZNF391, HMG20A, E2F7, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, SFMBT1, LYL1, ZNF274, INSM2, NFIC, ZNF90, ZNF362, CTCFL, PRDM1, KLF14, MECOM, HDAC3, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, USF2, TCF12, BAF155, EP300, GATA6, PRDM4, GLI4, CREB3, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, RUNX1T1, ID3, CDK7, GATAD1, GMEB2, ARID3A, ZNF585B, ASCL1, MIER1, ZNF341, USP7, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, ZNF750, FEZF1, HES1, ZNF664, TFE3, HBP1, IRF1, SREBF1, ZGPAT, NAB2, MRTFB, MYF5, ATF1, PTBP1, CBX1, MAFG, SMC1A, SIRT6, ZNF335, ZFX, FIP1L1, ZNF534, SMAD3, NMYC, TWIST1, NSD2, IRF2, PRPF4, NOTCH1, BRD9, RUNX2, ZSCAN30, CDK6, GATA4, ZNF184, OSR2, NRF1, NR2C1, SUPT5H, FOS, CHD1, TGIF2, MED1, KDM6B, MYB, CEBPD, VEZF1, ZNF3, L3MBTL2, SETDB1, HIF2A, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, PHIP, TCF3, ZNF783, SKI, NELFA, NCOA4, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, FOXF1, ZBTB33, CDK9, HOXB13, ZNF589, YY1, ZNF148, ASXL1, ZNF610, SP140, BRCA1, HIF1A, OTX2, ZNF740, ZNF449, GATA1, HAND2, CEBPG, SP7, NCOA3, NR2F2, ZNF83, ZNF687, ZNF213, ZNF843, BHLHE40, NFKBIZ, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, NOTCH3, CLOCK, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): PCNT,C21orf58
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 8
  • Number of somatic mutations (non-coding): 2
  • Related genes and loops
  • Related gene: ENSG00000160298, ENSG00000160299,
  • Related loop: chr21:46146626-46148368~~chr21:46324586-46327028, chr21:46146642-46148386~~chr21:46324608-46326836, chr21:46284828-46287850~~chr21:46324624-46326392, chr21:46284891-46287117~~chr21:46325193-46327052, chr21:46284913-46287579~~chr21:46323099-46326350, chr21:46284994-46287562~~chr21:46323170-46326814, chr21:46285004-46287523~~chr21:46324190-46326305, chr21:46285202-46287572~~chr21:46324782-46326051, chr21:46285204-46287304~~chr21:46324596-46326067, chr21:46285206-46287083~~chr21:46324674-46326343, chr21:46285212-46287543~~chr21:46321861-46326303, chr21:46285216-46286892~~chr21:46324785-46326845, chr21:46285222-46287087~~chr21:46324856-46327070, chr21:46285272-46287549~~chr21:46324181-46326111,
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