- Basic information
- CohesinDB ID: CDBP00421509
- Locus: chr21-46353313-46359214
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Data sourse: GSE67783, GSE86191, GSE98367, GSE111913, ENCSR000EGW, GSE206145, GSE206145-NatGen2015, GSE62063, GSE120943, ENCSR153HNT, GSE83726, GSE50893
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Cell type: RH4, GM2610, RPE, GM2630, Fibroblast, GM12890, GM2255, K-562, Monocytes, GM12878, GM12891, GM2588, GM19239, RT-112, Macrophage, GM19099, Ramos, HCT-116, GM19238, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 6% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.778
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: False
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
88% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"4_Tx": 52%,
"5_TxWk": 39%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: HMGN3, NME2, XBP1, FOXA1, RBFOX2, LEO1, ZFHX2, ATF3, THAP1, ZNF362, PRDM1, CBFB, GLYR1, TP63, MITF, BACH2, TRIM28, ETV1, SNAI2, SMAD5, LMO2, OCA2, TP73, ESR1, USF2, CTCF, JUN, BAF155, MNT, IRF4, GTF2F1, TFAP2C, EED, JARID2, MYCN, POU5F1, ZNF263, ID3, ZNF317, ZBTB48, ZSCAN5A, STAT1, ZNF205, ERG2, ERG, ASCL1, OGG1, ZNF341, MYC, SMARCA4, FOXP2, GRHL3, STAT3, NKX3-1, PRDM14, DNMT3B, SRSF3, CREB1, EZH2, GRHL2, SPI1, GATA2, SSRP1, SIX2, FLI1, HCFC1R1, RUNX1, BCL6, SIRT6, ZFX, TET2, ERG3, NSD2, RARA, TAF15, ARNT, PBX3, NCAPH2, FOS, SUPT5H, CHD1, MED1, KDM6B, MYB, PIAS1, ZNF3, NCOA1, SETDB1, SREBF2, RBM22, MAFK, REST, ASH2L, BCOR, AATF, STAG1, TRP47, CBFA2T2, MEF2B, ZNF316, FOXA2, PAF1, ZNF600, WT1, MEF2C, CDK9, HOXB13, YY1, RELA, SP140, TCF4, HIF1A, BHLHE22, TAL1, AGO2, PLAG1, BCL11B, NR2F1, KDM5B, ZNF334, NFKB1, EGR2, AR, RXR, HEXIM1, HSF1, BRD4, MAZ, AHR
- Target gene symbol (double-evidenced CRMs): PCNT
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 113
- Number of somatic mutations (non-coding): 108
- Related genes and loops