- Basic information
- CohesinDB ID: CDBP00421592
- Locus: chr21-46545292-46547043
-
Data sourse: GSE67783, GSE86191, GSE111913, ShirahigeLab, GSE85526, ENCSR153HNT, GSE25021
-
Cell type: MCF-7, RPE, HCT-116, HEKn, RT-112, K-562, HSPC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 3% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.922
- Subunit: SA1,Rad21,SA2,SMC1
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: False
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
86% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"4_Tx": 69%,
"5_TxWk": 15%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: RUNX1, TRP47, POU2F2, SMC1A, PGR, CBX1, ZNF263, MYCN, FOSL1, ZSCAN5D, ZFX, CBFA2T2, EBF1, BRD1, ZBTB48, WT1, ZSCAN5A, FOXA1, XBP1, TET2, ERG3, TBL1X, ERG2, ZFHX2, NSD2, YY1, RELA, CREBBP, ATF3, MYC, AHR, SP140, ARNT, HIF1A, NRF1, GRHL3, MAX, TP63, FOS, ZNF143, CHD1, DNMT3B, AGO2, MED1, SMARCB1, TEAD1, NR2F1, ZNF3, ESR1, OCA2, TP53, KLF9, GRHL2, ZNF334, CHD8, TRIM25, EGR2, CTCF, RBM22, MAFK, RBM14, MNT, SSRP1, REST, EGLN2, HEXIM1, HSF1, HNRNPLL, BRD4, MAZ, AATF, SMC3, STAG1, TFAP2C
- Target gene symbol (double-evidenced CRMs): DIP2A
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 250
- Number of somatic mutations (non-coding): 50
- Related genes and loops